2026-08-01_00000449|ligand|9ZOF

Cryo-EM structure of the complete Sulfolobus acidocaldarius RNA polymerase in closed clamp conformation; Electron microscopy 3.37Å
Protein #1 880 residues (100% resolved)

MSEKIIRGVKFGVLSPNEIRQMSVTAIITSEVYDEDGTPIEGGVMDPKLGVIEPGQKCPVCGNTLAGCPGHFGHIELIKPVIHIGYVKHIYDFLRSTCWRCGRIKIKEQDLERYKRIYNAIKLRWPSAARRLVEYIKKISIKNLECPHCGEKQFKIKLEKPYNFNEERNGSIVKLSPSEIRDRLERIPDSDVELLGYDPKSSRPEWMILTVLPVPPITIRPSITIESGIRAEDDLTHKLVDIIRLNERLKESIEAGAPQLIIEDLWDLLQYHVATYFDNEIPGLPPAKHRSGRPLRTLAQRLKGKEGRFRGNLSGKRVDFSARTVISPDPNLSIDEVGIPYTIARMLTVPERVTNINIERIRQYIINGPDKWPGANYVIKPDGRRIDLRYVKDRKELASSITAGYVVERHLVDGDVVLFNRQPSLHRISMMAHKVRVLPGRTFRLNLLDCPPYNADFDGDEMNLHVPQSEEAIAEARELMLVHKNIITPRYGGPIIGGGQDYISGAYLLSVKTTLLTVEEVATILGVTDFVGELGEPAILAPKPYYTGKQVISLFLPKDFNFHGPANISKGPRACKDEICPHDSFIVIKNGLLLEGVFDKKAIGNQQPESMLHWSIREYGTEYGKWLMDNVFKMFIRFLEMRGFTMTLEDITIPDEAQNEITTKIKEGYSQVDEYIRKFNEGQLEPIPGRTIEESLESYILDTLDKLRKVAGEIATKYLDPFNNVYIMAITGARGSELNITQMTALLGQQSVRGERIRRGYRERTLSLFKYGDIAPEARGFVKNSFMRGLSPYEMFFHAAGGREGLVDTAVKTSQSGYMQRRLINALSDLRIEYDGTVRSLYGDIVQVVYGDDAVHPMYSAHSKSVNVNRVIERVIGWKR

MSEKIIRGVKFGVLSPNEIRQMSVTAIITSEVYDEDGTPIEGGVMDPKLGVIEPGQKCPVCGNTLAGCPGHFGHIELIKPVIHIGYVKHIYDFLRSTCWRCGRIKIKEQDLERYKRIYNAIKLRWPSAARRLVEYIKKISIKNLECPHCGEKQFKIKLEKPYNFNEERNGSIVKLSPSEIRDRLERIPDSDVELLGYDPKSSRPEWMILTVLPVPPITIRPSITIESGIRAEDDLTHKLVDIIRLNERLKESIEAGAPQLIIEDLWDLLQYHVATYFDNEIPGLPPAKHRSGRPLRTLAQRLKGKEGRFRGNLSGKRVDFSARTVISPDPNLSIDEVGIPYTIARMLTVPERVTNINIERIRQYIINGPDKWPGANYVIKPDGRRIDLRYVKDRKELASSITAGYVVERHLVDGDVVLFNRQPSLHRISMMAHKVRVLPGRTFRLNLLDCPPYNADFDGDEMNLHVPQSEEAIAEARELMLVHKNIITPRYGGPIIGGGQDYISGAYLLSVKTTLLTVEEVATILGVTDFVGELGEPAILAPKPYYTGKQVISLFLPKDFNFHGPANISKGPRACKDEICPHDSFIVIKNGLLLEGVFDKKAIGNQQPESMLHWSIREYGTEYGKWLMDNVFKMFIRFLEMRGFTMTLEDITIPDEAQNEITTKIKEGYSQVDEYIRKFNEGQLEPIPGRTIEESLESYILDTLDKLRKVAGEIATKYLDPFNNVYIMAITGARGSELNITQMTALLGQQSVRGERIRRGYRERTLSLFKYGDIAPEARGFVKNSFMRGLSPYEMFFHAAGGREGLVDTAVKTSQSGYMQRRLINALSDLRIEYDGTVRSLYGDIVQVVYGDDAVHPMYSAHSKSVNVNRVIERVIGWKR
Protein #2 1126 residues (98% resolved)

MLDTESRWAIAESFFKTRGLVRQHLDSFNDFLRNKLQQVIYEQGEIVTEVPGLKIKLGKIRYEKPSIRETDKGPMREITPMEARLRNLTYSSPIFLSMIPVENNIEGEPIEIYIGDLPIMLKSVADPTSNLPIDKLIEIGEDPKDPGGYFIVNGSEKVIIAQEDLATNRVLVDYGKSGSNITHVAKVTSSAAGYRVQVMIERLKDSTIQISFATVPGRIPFAIIMRALGFVTDRDIVYAVSLDPQIQNELLPSLEQASSITSAEEALDFIGNRVAIGQKRENRIQKAEQVIDKYFLPHLGTSPEDRKKKGYYLASAVNKILELYLGRREPDDKDHYANKRVRLAGDLFTSLFRVAFKAFVKDLVYQLEKSKVRGRRLSLTALVRADIITERIRHALATGNWVGGRTGVSQLLDRTNWLSMLSHLRRVVSSLARGQPNFEARDLHGTQWGRMCPFETPEGPNSGLVKNLALLAQVSVGINESVVERVAYELGVVSVEDVIRRISEQNEDVEKYMSWSKVYLNGRLLGYYEDGKELAKKIRESRRQGKLSDEVNVAYIATDYLNEVHINCDAGRVRRPLIIVNNGTPLVDTEDIKKLKNGEITFDDLVKQGKIEFIDAEEEENAYVALNPQDLTPDHTHLEIWPSAILGIIASIIPYPEHNQSPRNTYQSAMAKQSLGLYASNYQIRTDTRAHLLHYPQMPLVQTRMLGVIGYNDRPAGANAILAIMSYTGYNMEDSIIMNKSSIERGMYRSTFFRLYSTEEVKYPGGQEDKIITPEAGVKGYKGKDYYRLLEDNGVVSPEVEVKGGDVLIGKVSPPRFLQEFKELSPEQAKRDTSIVTRHGENGIVDLVLITETLEGNKLVKVRVRDLRIPEIGDKFATRHGQKGVVGILIDQVDMPYTAKGIVPDIILNPHALPSRMTIGQIMEAIGGKYAALSGKPVDATPFLETPKLQEMQKEILKLGHLPDSTEVVYDGRTGQKLKSRILFGIVYYQKLHHMVADKMHARARGPVQILTRQPTEGRAREGGLRFGEMERDCLIGFGTAMLIKDRLLDNSDKAVVYICDQCGYVGWYDRSKNRYVCPVHGDKSVLHPVTVSYAFKLLIQELMSMVISPRLILGEKVNLGGASNE

MLDTESRWAIAESFFKTRGLVRQHLDSFNDFLRNKLQQVIYEQGEIVTEVPGLKIKLGKIRYEKPSIRETDKGPMREITPMEARLRNLTYSSPIFLSMIPVENNIEGEPIEIYIGDLPIMLKSVADPTSNLPIDKLIEIGEDPKDPGGYFIVNGSEKVIIAQEDLATNRVLVDYGKSGSNITHVAKVTSSAAGYRVQVMIERLKDSTIQISFATVPGRIPFAIIMRALGFVTDRDIVYAVSLDPQIQNELLPSLEQASSITSAEEALDFIGNRVAIGQKRENRIQKAEQVIDKYFLPHLGTSPEDRKKKGYYLASAVNKILELYLGRREPDDKDHYANKRVRLAGDLFTSLFRVAFKAFVKDLVYQLEKSKVRGRRLSLTALVRADIITERIRHALATGNWVGGRTGVSQLLDRTNWLSMLSHLRRVVSSLARGQPNFEARDLHGTQWGRMCPFETPEGPNSGLVKNLALLAQVSVGINESVVERVAYELGVVSVEDVIRRISEQNEDVEKYMSWSKVYLNGRLLGYYEDGKELAKKIRESRRQGKLSDEVNVAYIATDYLNEVHINCDAGRVRRPLIIVNNGTPLVDTEDIKKLKNGEITFDDLVKQGKIEFIDAEEEENAYVALNPQDLTPDHTHLEIWPSAILGIIASIIPYPEHNQSPRNTYQSAMAKQSLGLYASNYQIRTDTRAHLLHYPQMPLVQTRMLGVIGYNDRPAGANAILAIMSYTGYNMEDSIIMNKSSIERGMYRSTFFRLYSTEEVKYPGGQEDKIITPEAGVKGYKGKDYYRLLEDNGVVSPEVEVKGGDVLIGKVSPPRFLQEFKELSPEQAKRDTSIVTRHGENGIVDLVLITETLEGNKLVKVRVRDLRIPEIGDKFATRHGQKGVVGILIDQVDMPYTAKGIVPDIILNPHALPSRMTIGQIMEAIGGKYAALSGKPVDATPFLETPKLQEMQKEILKLGHLPDSTEVVYDGRTGQKLKSRILFGIVYYQKLHHMVADKMHARARGPVQILTRQPTEGRAREGGLRFGEMERDCLIGFGTAMLIKDRLLDNSDKAVVYICDQCGYVGWYDRSKNRYVCPVHGDKSVLHPVTVSYAFKLLIQELMSMVISPRLILGEKVNLGGASNE
Protein #3 393 residues (98% resolved)

MIDEKLKGYIDKRLNEIKDKIPDKLHEDLRAAIMDINGVELTEEDIDRIIDLTIREYQQSLIEPGEAIGVVTAQSVGEPGTQMTLRTFHFAGIRELNVTLGLPRLIEIVDARKVPSTPMMTIYLTDEYKTDKDKALDIARRIEYTRVENVVSSVSVDISNMSITLQFDQEMLKDKGVSIEEIKKIITKLKLGEIRIEDNDEYSFTIYFEKIDSIMALFKMREKILNTKIKGVKGIKRAIVQKKGDEYVIITDGSNLEGIMNVTGVDINKIQTNNIHEVEEVLGIEAARELISREIKKVLEEQGLDVDMRHIVLVSDIMTRTGDIRQIGRHGVTGEKSSVLARAAFEVTVKHLLDAAARGEREEFKGVIENIIIGQPIRLGTGIVELTMKPNMR

MIDEKLKGYIDKRLNEIKDKIPDKLHEDLRAAIMDINGVELTEEDIDRIIDLTIREYQQSLIEPGEAIGVVTAQSVGEPGTQMTLRTFHFAGIRELNVTLGLPRLIEIVDARKVPSTPMMTIYLTDEYKTDKDKALDIARRIEYTRVENVVSSVSVDISNMSITLQFDQEMLKDKGVSIEEIKKIITKLKLGEIRIEDNDEYSFTIYFEKIDSIMALFKMREKILNTKIKGVKGIKRAIVQKKGDEYVIITDGSNLEGIMNVTGVDINKIQTNNIHEVEEVLGIEAARELISREIKKVLEEQGLDVDMRHIVLVSDIMTRTGDIRQIGRHGVTGEKSSVLARAAFEVTVKHLLDAAARGEREEFKGVIENIIIGQPIRLGTGIVELTMKPNMR
Protein #4 124 residues (98% resolved)

MKEMMQGTCKISSIEKGALKNLYVVKMDCDNDLKIEFDITKELSIFSKDEEVTFIISREKPEYSEKDFCAHGYLFLERQQEDGSFIDEISLYGLIVKILSKNGLINSKLFKMMDHVYYCVKKKA

MKEMMQGTCKISSIEKGALKNLYVVKMDCDNDLKIEFDITKELSIFSKDEEVTFIISREKPEYSEKDFCAHGYLFLERQQEDGSFIDEISLYGLIVKILSKNGLINSKLFKMMDHVYYCVKKKA
Protein #5 84 residues (93% resolved)

MRSSSKKKIDISNHELVPKHEILQLEEAYKLVKELGIKPEQLPWIRASDPVAKSIGAKPGDIIKITRKSPFTGESVTYRYVITG

MRSSSKKKIDISNHELVPKHEILQLEEAYKLVKELGIKPEQLPWIRASDPVAKSIGAKPGDIIKITRKSPFTGESVTYRYVITG
Protein #6 89 residues (97% resolved)

MTIDKINEIFKENWKNKLTKYEIARIISARALQLSMGALPLIDTSNLKSDDVISIAEEELKRGVLPITIRRIYPNGQVELISVRKIENR

MTIDKINEIFKENWKNKLTKYEIARIISARALQLSMGALPLIDTSNLKSDDVISIAEEELKRGVLPITIRRIYPNGQVELISVRKIENR
Protein #7 90 residues (100% resolved)

MEIKVIKEEQNYLELQIDGEEHTIGNLLKGMLLKVPGVKFAAYSLPHPLITSITIKILTDGSISAREALIKAIELAENYANLFIDEVKKI

MEIKVIKEEQNYLELQIDGEEHTIGNLLKGMLLKVPGVKFAAYSLPHPLITSITIKILTDGSISAREALIKAIELAENYANLFIDEVKKI
Protein #8 66 residues (100% resolved)

MIIPIRCFTCGAVVADKWEPFSNRVMGGEDPEKVLTELGVNRYCCRRMLLSHVNIIREIIHYTRPI

MIIPIRCFTCGAVVADKWEPFSNRVMGGEDPEKVLTELGVNRYCCRRMLLSHVNIIREIIHYTRPI
Protein #9 105 residues (42% resolved)

MSEDDSKKEPEPEETEAEIKHEEISREEDDEGGEFSTVTISDIEMLLKDTEIWDKLLRNELSIEEAKKMFDDVARSYSKADKKKRRVEKKPKKGKVTKKSDEEEE

MSEDDSKKEPEPEETEAEIKHEEISREEDDEGGEFSTVTISDIEMLLKDTEIWDKLLRNELSIEEAKKMFDDVARSYSKADKKKRRVEKKPKKGKVTKKSDEEEE
Protein #10 183 residues (97% resolved)

MFKLVRAKGIVRIPPEYFGQSVDEIAIKILRQEYQEKLIKDIGVVLGIVNAKASEEGFIIFGDGATYHEVEFDMLVYTPIIHEVIEGEVSQVDNYGVYVNMGPVDGLVHISQITDDNLKFDSNRGILIGEKSKKSIQKGDRVRAMIISASMSSGRLPRIALTMKQPYLGKIEWINQEIAKASK

MFKLVRAKGIVRIPPEYFGQSVDEIAIKILRQEYQEKLIKDIGVVLGIVNAKASEEGFIIFGDGATYHEVEFDMLVYTPIIHEVIEGEVSQVDNYGVYVNMGPVDGLVHISQITDDNLKFDSNRGILIGEKSKKSIQKGDRVRAMIISASMSSGRLPRIALTMKQPYLGKIEWINQEIAKASK
Protein #11 264 residues (99% resolved)

MPISLIERNGLRLRLVLENYPLEFVNSIRRASILYVPVMAVDEVYFIENNSPLYDEILAHRLALVPFVSDEALEHYRPPEECAECKENCDGCYNRVYLDVEAKDQPLMIYSRDLKSEDQMITPVSGAIPIVLLGSKQKISLEARLRLGYGKEHIKYSPVSVSIVRYYPKVTVLGNCEKAVEVCPEGVFAMENNKLVVKNELSCILCEECLKYCAGSVSIESVENKFILEIESVGSLKPERILIEASKSLLRKLSELKSKLEAGK

MPISLIERNGLRLRLVLENYPLEFVNSIRRASILYVPVMAVDEVYFIENNSPLYDEILAHRLALVPFVSDEALEHYRPPEECAECKENCDGCYNRVYLDVEAKDQPLMIYSRDLKSEDQMITPVSGAIPIVLLGSKQKISLEARLRLGYGKEHIKYSPVSVSIVRYYPKVTVLGNCEKAVEVCPEGVFAMENNKLVVKNELSCILCEECLKYCAGSVSIESVENKFILEIESVGSLKPERILIEASKSLLRKLSELKSKLEAGK
Protein #12 48 residues (98% resolved)

MAKYRCGKCWKELDDDQLKTLPGVRCPYCGYRIIYMVRKPTVKIVKAI

MAKYRCGKCWKELDDDQLKTLPGVRCPYCGYRIIYMVRKPTVKIVKAI
Protein #13 114 residues (96% resolved)

MSYSLKTIEEHFVPYSIAKKYIKELIDTGSSSNLIQKTFDYLNSISRCDEDSASKIMKELEEIVKREDVRAVLASICPTTVEEVRSVLVIDPSTIYSTEQIQKIIEIIKKYVES

MSYSLKTIEEHFVPYSIAKKYIKELIDTGSSSNLIQKTFDYLNSISRCDEDSASKIMKELEEIVKREDVRAVLASICPTTVEEVRSVLVIDPSTIYSTEQIQKIIEIIKKYVES
Non polymer #14 SF4

InChI=1S/4Fe.4S

[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
Non polymer #15 ZN

InChI=1S/Zn/q+2

[Zn+2]
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Reference