2026-08-01_00000416|hard|9YDW

Cryo-EM structure of single-bound FDG antibody VRC49.01 in complex with HIV-1 Env BG505 DS-SOSIP trimer; Electron microscopy 3.34Å
Protein #1 153 residues (83% resolved)

AVGIGAVFLGFLGAAGSTMGAASMTLTVQARNLLSGIVQQQSNLLRAPEAQQHLLKLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD

AVGIGAVFLGFLGAAGSTMGAASMTLTVQARNLLSGIVQQQSNLLRAPEAQQHLLKLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD
Protein #2 481 residues (94% resolved)

AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGRRRRRR

AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGRRRRRR
Protein #3 125 residues (99% resolved)

QVHLVESGGGLAQPGGSLRLSCTASGFVFTDYDMHWVRLTTGRRLQWVSSVGTRSDTFYAVSVKGRFSISRDNTRNSVSLQMNNLRPGDTGIYFCTRGPYCNCHACVVDDAFDLWGQGTTVIVSS

QVHLVESGGGLAQPGGSLRLSCTASGFVFTDYDMHWVRLTTGRRLQWVSSVGTRSDTFYAVSVKGRFSISRDNTRNSVSLQMNNLRPGDTGIYFCTRGPYCNCHACVVDDAFDLWGQGTTVIVSS
Protein #4 107 residues (100% resolved)

DIQMTQSPSSISASLGDRVSITCRATQDIGNRLAWFQQRPGEIPKRLIYAGSTLQNGVPSRFGASGSGTQFTLTINSLQPEDSAIYFCLQHLNYPRTFGQGTTVQVK

DIQMTQSPSSISASLGDRVSITCRATQDIGNRLAWFQQRPGEIPKRLIYAGSTLQNGVPSRFGASGSGTQFTLTINSLQPEDSAIYFCLQHLNYPRTFGQGTTVQVK
Non polymer #5 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
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Reference