2026-08-01_00000347
|
ligand
|
9W2L
Crystal structure of FGFR2 with a macrocyclic compound XS9001;
X-ray diffraction 2.10Å
Protein #1
315 residues (95% resolved)
Raw Sequence ...
GPDTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE
Canonical Sequence ...
GPDTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE
Non polymer #2
A1EVI
InChI=1S/C24H24N6O4/c1-28-4-6-32-7-8-34-23-18(17-12-26-29(2)14-17)11-21-25-13-20(30(21)27-23)16-9-15-3-5-33-22(15)19(10-16)24(28)31/h9-14H,3-8H2,1-2H3
InChI=1S/C24H24N6O4/c1-28-4-6-32-7-8-34-23-18(17-12-26-29(2)14-17)11-21-25-13-20(30(21)27-23)16-9-15-3-5-33-22(15)19(10-16)24(28)31/h9-14H,3-8H2,1-2H3
SMILES: Cn1cc(cn1)c2cc3ncc-4n3nc2OCCOCCN(C(=O)c5cc4cc6c5OCC6)C
Cn1cc(cn1)c2cc3ncc-4n3nc2OCCOCCN(C(=O)c5cc4cc6c5OCC6)C
Biounit #1
homo-dimer
Download coordinates
Tube
Model
Reference
100%