2026-08-01_00000247|hard|9N3Z

Type IV-A1 CRISPR effector complex bound to dsDNA and CasDinG - locked state; Electron microscopy 3.04Å
Protein #1 241 residues (100% resolved)

MRYPSDIVDQVLKAGPDKGLLTWEGVDAACSHCSRPIQNGDLYSPSSVGAFFSDTRDLASTSRSICWRCVVLRKKPMLYGLSAAVVTQDGIYSISKDVNKAWLFTTPPPAPFLVVHSSSTMQHLSWRTPVTLDNRRIHVRYGPNLFIVRPEVVRKALSIADRVNEGQKKWVTPVYFDRKAAAMGHGLITRAGAEMLTQEEQEFFQSVTPGERWALSYLMHSKRPEPEVGECITEKVMTSLN

MRYPSDIVDQVLKAGPDKGLLTWEGVDAACSHCSRPIQNGDLYSPSSVGAFFSDTRDLASTSRSICWRCVVLRKKPMLYGLSAAVVTQDGIYSISKDVNKAWLFTTPPPAPFLVVHSSSTMQHLSWRTPVTLDNRRIHVRYGPNLFIVRPEVVRKALSIADRVNEGQKKWVTPVYFDRKAAAMGHGLITRAGAEMLTQEEQEFFQSVTPGERWALSYLMHSKRPEPEVGECITEKVMTSLN
Protein #2 220 residues (100% resolved)

MVNLKVTIDLSNPMMEPGDLLHLDALLGALRVSRARAEHGDAINPRDYHYDLPLERYQAPSGDWVFKASAFKLKRQLPNQMWMQTGRLSIVEAARHRQSGYLQLRAGKPNPAGGPFKTSIYHRPIVQAELTAFCVGDQQGIEALLSECRQIGGKRGVGFGQVAGFKVEPVAETDCPWSWRALPADADPRLVTSEHARCIAAIRGPYWDRTLHVEALAPTP

MVNLKVTIDLSNPMMEPGDLLHLDALLGALRVSRARAEHGDAINPRDYHYDLPLERYQAPSGDWVFKASAFKLKRQLPNQMWMQTGRLSIVEAARHRQSGYLQLRAGKPNPAGGPFKTSIYHRPIVQAELTAFCVGDQQGIEALLSECRQIGGKRGVGFGQVAGFKVEPVAETDCPWSWRALPADADPRLVTSEHARCIAAIRGPYWDRTLHVEALAPTP
Protein #3 359 residues (93% resolved)

MWSHPQFEKGAMQIEVTVRNITPIFSAAPGSNYITIDGTINPPPGVSRFPLVRTRMMYVAADVGDGVIKSVPLQIVPGNTMRSLLRRTMLKHVIEPALVEKGNKLSIGAYATAYSGNATGNPDGVPSSFDEIATMRAHPFIGLFGGGPRMLEGRLMVDSLYPIHTNAERILGAGYENEMMSGPITQVVWARRMDPILNLGSSEDVEVINGGAVAANGWIQDLLANSKAAASKKKKAAADEDESDGAAEENGRGLKAFNAHEVVIPGLKWVWRISLDRPTDAQVGLVLLALNKMTNERIAGGHSKDYGRFVIDGVSLNGEQVWSQSGITGGEQYFDAVAEAIDGLSSKEFEQFAQSAKEA

MWSHPQFEKGAMQIEVTVRNITPIFSAAPGSNYITIDGTINPPPGVSRFPLVRTRMMYVAADVGDGVIKSVPLQIVPGNTMRSLLRRTMLKHVIEPALVEKGNKLSIGAYATAYSGNATGNPDGVPSSFDEIATMRAHPFIGLFGGGPRMLEGRLMVDSLYPIHTNAERILGAGYENEMMSGPITQVVWARRMDPILNLGSSEDVEVINGGAVAANGWIQDLLANSKAAASKKKKAAADEDESDGAAEENGRGLKAFNAHEVVIPGLKWVWRISLDRPTDAQVGLVLLALNKMTNERIAGGHSKDYGRFVIDGVSLNGEQVWSQSGITGGEQYFDAVAEAIDGLSSKEFEQFAQSAKEA
Protein #4 232 residues (100% resolved)

MFVKQVFFDLGARIHADEARALVAKLLDDTQPGLVSALMNYMPASKTSKTEFPLVQFSNFNQGFALLGFGEVGAQILSDATPIIHDAMAKLFASRGQGVVVQVSSRDVPLSCEKRPYGLQYTVAKMVVQKKHEHRERLANPETGKVFLEGLFLRSLERQAAAVGMVLPRDLVVSFKGAERVSSVKLRPDSTLAHGSLRHAVFEVNARLGGLWSVGFLLSKGFGHINTDLQLG

MFVKQVFFDLGARIHADEARALVAKLLDDTQPGLVSALMNYMPASKTSKTEFPLVQFSNFNQGFALLGFGEVGAQILSDATPIIHDAMAKLFASRGQGVVVQVSSRDVPLSCEKRPYGLQYTVAKMVVQKKHEHRERLANPETGKVFLEGLFLRSLERQAAAVGMVLPRDLVVSFKGAERVSSVKLRPDSTLAHGSLRHAVFEVNARLGGLWSVGFLLSKGFGHINTDLQLG
RNA #5 61 bases

GUGAACGGUGGAGCAACACCUGAAGGAAGGCUUGAUGAGCGUGUUCCCCGCAUACGCGGGG

GUGAACGGUGGAGCAACACCUGAAGGAAGGCUUGAUGAGCGUGUUCCCCGCAUACGCGGGG
DNA #6 47 bases

(DT)(DC)(DA)(DC)(DG)(DC)(DT)(DA)(DG)(DT)(DG)(DG)(DA)(DG)(DC)(DA)(DA)(DC)(DA)(DC)(DC)(DT)(DG)(DA)(DA)(DG)(DG)(DA)(DA)(DG)(DG)(DC)(DT)(DT)(DG)(DA)(DT)(DG)(DA)(DG)(DC)(DA)(DA)(DG)(DT)(DG)(DC)

TCACGCTAGTGGAGCAACACCTGAAGGAAGGCTTGATGAGCAAGTGC
DNA #7 47 bases

(DG)(DC)(DA)(DC)(DT)(DT)(DG)(DC)(DT)(DC)(DA)(DT)(DC)(DA)(DA)(DG)(DC)(DC)(DT)(DT)(DC)(DC)(DT)(DT)(DC)(DA)(DG)(DG)(DT)(DG)(DT)(DT)(DG)(DC)(DT)(DC)(DC)(DA)(DC)(DT)(DA)(DG)(DC)(DG)(DT)(DG)(DA)

GCACTTGCTCATCAAGCCTTCCTTCAGGTGTTGCTCCACTAGCGTGA
Protein #8 748 residues (81% resolved)

MASWSHPQFEKGAENLYFQSNAMKLAQGAFVDVIRIGALSPPTDQRSLWARTLLSEAVDQGLDSLPVPLQDVSTFTVTLQPALAVRLKALADQHNTPVSVYAAGLIEAMRRRSESGSVAEAPMELPADALPGEGAVREVLRPLLKQAAEKTAAGKIVFAEAATGTGKGRMIASLAAAAAIKGDTVVVSAPLAVTWQLVNDMKDIPEVRRVGLTLSLGRPNFISPQRTLEWAIDNERADLAAWIEGGGKPLSLRSMETSKVISHELCWLLEDALLLAEDLPADSLLLTSEDPADCPAQQLYVAMRSNYTEAGIILCSHFMLAAHTRMMQMRGLGNDEELDDEAPTGLSLPHFIDTLIVDEAHLLEQAFASVYTHTLRLRPLMRTIEGLGSRGRKPALDALKELFTQMQVASARSTNTSLNVPLSDVPELIPALKDTVKTLGALPTKGMSRDARSVIRIATRAANDALSGHSRLRIEVTPVHSYPMLLSGRSNLQRALLGLWNATGGATLVSATLFTTGDNGSLTRWKLEVPTERAAFLPPVHPAWTTAPVLLHKEFCAHEPDDSPEWATECAQTIQGVASTAQGGTLVLCTSYQNTELLAGRLGAALGDRLIVQSKTSSAATCLAQFKAKHKAGIRPVWLGLGAAWTGIDLSDHSLPDNPELDRLLSDLVITRIPVGQNRSLTHERRTAIGGFRIISQEAAWHFRQGLGRLVRRPGVTHKNLWVLDARIYGGAAWVAPFRQILDRYKKA

MASWSHPQFEKGAENLYFQSNAMKLAQGAFVDVIRIGALSPPTDQRSLWARTLLSEAVDQGLDSLPVPLQDVSTFTVTLQPALAVRLKALADQHNTPVSVYAAGLIEAMRRRSESGSVAEAPMELPADALPGEGAVREVLRPLLKQAAEKTAAGKIVFAEAATGTGKGRMIASLAAAAAIKGDTVVVSAPLAVTWQLVNDMKDIPEVRRVGLTLSLGRPNFISPQRTLEWAIDNERADLAAWIEGGGKPLSLRSMETSKVISHELCWLLEDALLLAEDLPADSLLLTSEDPADCPAQQLYVAMRSNYTEAGIILCSHFMLAAHTRMMQMRGLGNDEELDDEAPTGLSLPHFIDTLIVDEAHLLEQAFASVYTHTLRLRPLMRTIEGLGSRGRKPALDALKELFTQMQVASARSTNTSLNVPLSDVPELIPALKDTVKTLGALPTKGMSRDARSVIRIATRAANDALSGHSRLRIEVTPVHSYPMLLSGRSNLQRALLGLWNATGGATLVSATLFTTGDNGSLTRWKLEVPTERAAFLPPVHPAWTTAPVLLHKEFCAHEPDDSPEWATECAQTIQGVASTAQGGTLVLCTSYQNTELLAGRLGAALGDRLIVQSKTSSAATCLAQFKAKHKAGIRPVWLGLGAAWTGIDLSDHSLPDNPELDRLLSDLVITRIPVGQNRSLTHERRTAIGGFRIISQEAAWHFRQGLGRLVRRPGVTHKNLWVLDARIYGGAAWVAPFRQILDRYKKA
Non polymer #9 ZN

InChI=1S/Zn/q+2

[Zn+2]
Download coordinates
Reference