2026-08-01_00000246|hard|9N3Y

Type IV-A1 CRISPR effector complex bound to dsDNA and CasDinG - loaded state; Electron microscopy 3.00Å
Protein #1 220 residues (100% resolved)

MVNLKVTIDLSNPMMEPGDLLHLDALLGALRVSRARAEHGDAINPRDYHYDLPLERYQAPSGDWVFKASAFKLKRQLPNQMWMQTGRLSIVEAARHRQSGYLQLRAGKPNPAGGPFKTSIYHRPIVQAELTAFCVGDQQGIEALLSECRQIGGKRGVGFGQVAGFKVEPVAETDCPWSWRALPADADPRLVTSEHARCIAAIRGPYWDRTLHVEALAPTP

MVNLKVTIDLSNPMMEPGDLLHLDALLGALRVSRARAEHGDAINPRDYHYDLPLERYQAPSGDWVFKASAFKLKRQLPNQMWMQTGRLSIVEAARHRQSGYLQLRAGKPNPAGGPFKTSIYHRPIVQAELTAFCVGDQQGIEALLSECRQIGGKRGVGFGQVAGFKVEPVAETDCPWSWRALPADADPRLVTSEHARCIAAIRGPYWDRTLHVEALAPTP
Protein #2 232 residues (97% resolved)

MFVKQVFFDLGARIHADEARALVAKLLDDTQPGLVSALMNYMPASKTSKTEFPLVQFSNFNQGFALLGFGEVGAQILSDATPIIHDAMAKLFASRGQGVVVQVSSRDVPLSCEKRPYGLQYTVAKMVVQKKHEHRERLANPETGKVFLEGLFLRSLERQAAAVGMVLPRDLVVSFKGAERVSSVKLRPDSTLAHGSLRHAVFEVNARLGGLWSVGFLLSKGFGHINTDLQLG

MFVKQVFFDLGARIHADEARALVAKLLDDTQPGLVSALMNYMPASKTSKTEFPLVQFSNFNQGFALLGFGEVGAQILSDATPIIHDAMAKLFASRGQGVVVQVSSRDVPLSCEKRPYGLQYTVAKMVVQKKHEHRERLANPETGKVFLEGLFLRSLERQAAAVGMVLPRDLVVSFKGAERVSSVKLRPDSTLAHGSLRHAVFEVNARLGGLWSVGFLLSKGFGHINTDLQLG
RNA #3 61 bases

GUGAACGGUGGAGCAACACCUGAAGGAAGGCUUGAUGAGCGUGUUCCCCGCAUACGCGGGG

GUGAACGGUGGAGCAACACCUGAAGGAAGGCUUGAUGAGCGUGUUCCCCGCAUACGCGGGG
DNA #4 54 bases

(DA)(DA)(DC)(DT)(DC)(DA)(DC)(DG)(DC)(DT)(DA)(DG)(DT)(DG)(DG)(DA)(DG)(DC)(DA)(DA)(DC)(DA)(DC)(DC)(DT)(DG)(DA)(DA)(DG)(DG)(DA)(DA)(DG)(DG)(DC)(DT)(DT)(DG)(DA)(DT)(DG)(DA)(DG)(DC)(DA)(DA)(DG)(DT)(DG)(DC)(DG)(DG)(DC)(DA)

AACTCACGCTAGTGGAGCAACACCTGAAGGAAGGCTTGATGAGCAAGTGCGGCA
DNA #5 54 bases

(DT)(DG)(DC)(DC)(DG)(DC)(DA)(DC)(DT)(DT)(DG)(DC)(DT)(DC)(DA)(DT)(DC)(DA)(DA)(DG)(DC)(DC)(DT)(DT)(DC)(DC)(DT)(DT)(DC)(DA)(DG)(DG)(DT)(DG)(DT)(DT)(DG)(DC)(DT)(DC)(DC)(DA)(DC)(DT)(DA)(DG)(DC)(DG)(DT)(DG)(DA)(DG)(DT)(DT)

TGCCGCACTTGCTCATCAAGCCTTCCTTCAGGTGTTGCTCCACTAGCGTGAGTT
Protein #6 241 residues (100% resolved)

MRYPSDIVDQVLKAGPDKGLLTWEGVDAACSHCSRPIQNGDLYSPSSVGAFFSDTRDLASTSRSICWRCVVLRKKPMLYGLSAAVVTQDGIYSISKDVNKAWLFTTPPPAPFLVVHSSSTMQHLSWRTPVTLDNRRIHVRYGPNLFIVRPEVVRKALSIADRVNEGQKKWVTPVYFDRKAAAMGHGLITRAGAEMLTQEEQEFFQSVTPGERWALSYLMHSKRPEPEVGECITEKVMTSLN

MRYPSDIVDQVLKAGPDKGLLTWEGVDAACSHCSRPIQNGDLYSPSSVGAFFSDTRDLASTSRSICWRCVVLRKKPMLYGLSAAVVTQDGIYSISKDVNKAWLFTTPPPAPFLVVHSSSTMQHLSWRTPVTLDNRRIHVRYGPNLFIVRPEVVRKALSIADRVNEGQKKWVTPVYFDRKAAAMGHGLITRAGAEMLTQEEQEFFQSVTPGERWALSYLMHSKRPEPEVGECITEKVMTSLN
Protein #7 359 residues (92% resolved)

MWSHPQFEKGAMQIEVTVRNITPIFSAAPGSNYITIDGTINPPPGVSRFPLVRTRMMYVAADVGDGVIKSVPLQIVPGNTMRSLLRRTMLKHVIEPALVEKGNKLSIGAYATAYSGNATGNPDGVPSSFDEIATMRAHPFIGLFGGGPRMLEGRLMVDSLYPIHTNAERILGAGYENEMMSGPITQVVWARRMDPILNLGSSEDVEVINGGAVAANGWIQDLLANSKAAASKKKKAAADEDESDGAAEENGRGLKAFNAHEVVIPGLKWVWRISLDRPTDAQVGLVLLALNKMTNERIAGGHSKDYGRFVIDGVSLNGEQVWSQSGITGGEQYFDAVAEAIDGLSSKEFEQFAQSAKEA

MWSHPQFEKGAMQIEVTVRNITPIFSAAPGSNYITIDGTINPPPGVSRFPLVRTRMMYVAADVGDGVIKSVPLQIVPGNTMRSLLRRTMLKHVIEPALVEKGNKLSIGAYATAYSGNATGNPDGVPSSFDEIATMRAHPFIGLFGGGPRMLEGRLMVDSLYPIHTNAERILGAGYENEMMSGPITQVVWARRMDPILNLGSSEDVEVINGGAVAANGWIQDLLANSKAAASKKKKAAADEDESDGAAEENGRGLKAFNAHEVVIPGLKWVWRISLDRPTDAQVGLVLLALNKMTNERIAGGHSKDYGRFVIDGVSLNGEQVWSQSGITGGEQYFDAVAEAIDGLSSKEFEQFAQSAKEA
Protein #8 748 residues (82% resolved)

MASWSHPQFEKGAENLYFQSNAMKLAQGAFVDVIRIGALSPPTDQRSLWARTLLSEAVDQGLDSLPVPLQDVSTFTVTLQPALAVRLKALADQHNTPVSVYAAGLIEAMRRRSESGSVAEAPMELPADALPGEGAVREVLRPLLKQAAEKTAAGKIVFAEAATGTGKGRMIASLAAAAAIKGDTVVVSAPLAVTWQLVNDMKDIPEVRRVGLTLSLGRPNFISPQRTLEWAIDNERADLAAWIEGGGKPLSLRSMETSKVISHELCWLLEDALLLAEDLPADSLLLTSEDPADCPAQQLYVAMRSNYTEAGIILCSHFMLAAHTRMMQMRGLGNDEELDDEAPTGLSLPHFIDTLIVDEAHLLEQAFASVYTHTLRLRPLMRTIEGLGSRGRKPALDALKELFTQMQVASARSTNTSLNVPLSDVPELIPALKDTVKTLGALPTKGMSRDARSVIRIATRAANDALSGHSRLRIEVTPVHSYPMLLSGRSNLQRALLGLWNATGGATLVSATLFTTGDNGSLTRWKLEVPTERAAFLPPVHPAWTTAPVLLHKEFCAHEPDDSPEWATECAQTIQGVASTAQGGTLVLCTSYQNTELLAGRLGAALGDRLIVQSKTSSAATCLAQFKAKHKAGIRPVWLGLGAAWTGIDLSDHSLPDNPELDRLLSDLVITRIPVGQNRSLTHERRTAIGGFRIISQEAAWHFRQGLGRLVRRPGVTHKNLWVLDARIYGGAAWVAPFRQILDRYKKA

MASWSHPQFEKGAENLYFQSNAMKLAQGAFVDVIRIGALSPPTDQRSLWARTLLSEAVDQGLDSLPVPLQDVSTFTVTLQPALAVRLKALADQHNTPVSVYAAGLIEAMRRRSESGSVAEAPMELPADALPGEGAVREVLRPLLKQAAEKTAAGKIVFAEAATGTGKGRMIASLAAAAAIKGDTVVVSAPLAVTWQLVNDMKDIPEVRRVGLTLSLGRPNFISPQRTLEWAIDNERADLAAWIEGGGKPLSLRSMETSKVISHELCWLLEDALLLAEDLPADSLLLTSEDPADCPAQQLYVAMRSNYTEAGIILCSHFMLAAHTRMMQMRGLGNDEELDDEAPTGLSLPHFIDTLIVDEAHLLEQAFASVYTHTLRLRPLMRTIEGLGSRGRKPALDALKELFTQMQVASARSTNTSLNVPLSDVPELIPALKDTVKTLGALPTKGMSRDARSVIRIATRAANDALSGHSRLRIEVTPVHSYPMLLSGRSNLQRALLGLWNATGGATLVSATLFTTGDNGSLTRWKLEVPTERAAFLPPVHPAWTTAPVLLHKEFCAHEPDDSPEWATECAQTIQGVASTAQGGTLVLCTSYQNTELLAGRLGAALGDRLIVQSKTSSAATCLAQFKAKHKAGIRPVWLGLGAAWTGIDLSDHSLPDNPELDRLLSDLVITRIPVGQNRSLTHERRTAIGGFRIISQEAAWHFRQGLGRLVRRPGVTHKNLWVLDARIYGGAAWVAPFRQILDRYKKA
Non polymer #9 ZN

InChI=1S/Zn/q+2

[Zn+2]
Download coordinates
Reference