2026-08-01_00000206|ligand|31WC

Crystal structure of the HPK1 kinase domain in complex with inhibitor 12; X-ray diffraction 1.39Å
Protein #1 294 residues (98% resolved)

GSDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGAELARRLEFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKN

GSDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGAELARRLEFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKN
Non polymer #2 A1KCR

InChI=1S/C22H21N9O/c1-30-10-26-17-13(6-24-8-15(17)30)19-16(11-4-5-11)27-18-12(7-25-21(23)20(18)28-19)14-9-31(2)29-22(14)32-3/h6-11H,4-5H2,1-3H3,(H2,23,25)

Cn1cc(c(n1)OC)c2cnc(c3c2nc(c(n3)c4cncc5c4ncn5C)C6CC6)N
Non polymer #3 EDO

InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

C(CO)O
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Reference