2026-08-01_00000205|ligand|31WB

Crystal structure of the HPK1 kinase domain in complex with inhibitor 6b; X-ray diffraction 1.31Å
Protein #1 294 residues (97% resolved)

GSDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGAELARRLEFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKN

GSDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGAELARRLEFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKN
Non polymer #2 A1KCQ

InChI=1S/C26H25N7O2/c1-16-23(21-12-28-13-22-24(21)29-15-31(22)2)30-26-20(25(27)34)11-18(14-33(16)26)17-3-5-19(6-4-17)32-7-9-35-10-8-32/h3-6,11-15H,7-10H2,1-2H3,(H2,27,34)

Cc1c(nc2n1cc(cc2C(=O)N)c3ccc(cc3)N4CCOCC4)c5cncc6c5ncn6C
Non polymer #3 EDO

InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

C(CO)O
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Reference