2026-08-01_00000019|ligand|12FJ

Crystal structure of 6-fluoropyrazolo[1,5-a]pyridine derivative bound to KIT; X-ray diffraction 2.63Å
Protein #1 339 residues (92% resolved)

GPMDPTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHI

GPMDPTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHI
Non polymer #2 A1DJF

InChI=1S/C20H16F2N6O/c1-10-6-15(22)13(19-25-18(26-27-19)11-2-3-11)7-16(10)24-20(29)14-8-23-28-9-12(21)4-5-17(14)28/h4-9,11H,2-3H2,1H3,(H,24,29)(H,25,26,27)

Cc1cc(c(cc1NC(=O)c2cnn3c2ccc(c3)F)c4[nH]c(nn4)C5CC5)F
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