2026-07-25_00000368|hard|9Z60

Structure of the sodium-dependent phosphate importer SLC34A2, apo; Electron microscopy 3.53Å
Protein #1 646 residues (72% resolved)

GPEFATMAPRPKHEHESDEKQPETLDGARKKSLSMAPAVSTAALIEDDPWEMMELQDTGVKWADLDTKKKVLRVFTTAAKLIMLLGLLYMFVCSLDVLSSAFQLVGGKAAGDIFQENKVLSNPLAGLVIGMLVTLLVQSSSTSSSIVVSMVSSGMLEVATAVPIIMGTNIGTSVTNTLVAIAQVGDRNKFRRAFAGATVHDFFNWLSVLVLLPLEVASGYLEKVTSLIVRSFNIESGEKAPALLNVITDPLTHSIIQLDESVMSGIAVGDPEARNKSLIKVWCHTASNTTVQNVTTTNCTSPSLCWTDGIQNWTMKNVTEIINIKKCSHIFVNTSLSDLAVGLILLAGSLLILCTCLICIVKLLNSMLKGQVAVVIKKIVNTDFPFPFAWLTGYIAILVGAGMTFIVQSSSVFTSAITPLVGIGVISIERAYPLSLGSNIGTTTTAILAAMASPGETLGNSLQIALVHFFFNLSGILLWYPIPITRIPIRLAKGLGETTAQYRWFAAFYIILCFFGLPLLVFGLSMAGWQVLMGVLVPIAVILIFAIIVNILQKHKPQWLPSALRSWDFLPLWAHSLDPWDRVVTVIAARCCCCCKCCNSNEEDEKAKLENLANGIEINDNTMTTVEIIEPKKTVDSCEILKATSL

GPEFATMAPRPKHEHESDEKQPETLDGARKKSLSMAPAVSTAALIEDDPWEMMELQDTGVKWADLDTKKKVLRVFTTAAKLIMLLGLLYMFVCSLDVLSSAFQLVGGKAAGDIFQENKVLSNPLAGLVIGMLVTLLVQSSSTSSSIVVSMVSSGMLEVATAVPIIMGTNIGTSVTNTLVAIAQVGDRNKFRRAFAGATVHDFFNWLSVLVLLPLEVASGYLEKVTSLIVRSFNIESGEKAPALLNVITDPLTHSIIQLDESVMSGIAVGDPEARNKSLIKVWCHTASNTTVQNVTTTNCTSPSLCWTDGIQNWTMKNVTEIINIKKCSHIFVNTSLSDLAVGLILLAGSLLILCTCLICIVKLLNSMLKGQVAVVIKKIVNTDFPFPFAWLTGYIAILVGAGMTFIVQSSSVFTSAITPLVGIGVISIERAYPLSLGSNIGTTTTAILAAMASPGETLGNSLQIALVHFFFNLSGILLWYPIPITRIPIRLAKGLGETTAQYRWFAAFYIILCFFGLPLLVFGLSMAGWQVLMGVLVPIAVILIFAIIVNILQKHKPQWLPSALRSWDFLPLWAHSLDPWDRVVTVIAARCCCCCKCCNSNEEDEKAKLENLANGIEINDNTMTTVEIIEPKKTVDSCEILKATSL
Protein #2 228 residues (53% resolved)

QIQLVQSGPELKKPGETVKISCRASGYTFTNCGMNWVKQAPGKGLKWMGWINTYTGEPTYADDFKGRFAFSLETSANTAYLQISNLKNEDTATYFCARNYYYGSTYRGFDYWGQGTTLTVSSAKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTI

QIQLVQSGPELKKPGETVKISCRASGYTFTNCGMNWVKQAPGKGLKWMGWINTYTGEPTYADDFKGRFAFSLETSANTAYLQISNLKNEDTATYFCARNYYYGSTYRGFDYWGQGTTLTVSSAKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTI
Protein #3 218 residues (51% resolved)

DIVLTQSPASLAVSLGQRATISCRASESVDNFGISFMHWYHQKPGQPPKLLIYRASNLESGIPARFSGSGSGTDFTLTINPVEADDVATYFCQQSNEDPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC

DIVLTQSPASLAVSLGQRATISCRASESVDNFGISFMHWYHQKPGQPPKLLIYRASNLESGIPARFSGSGSGTDFTLTINPVEADDVATYFCQQSNEDPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC
Non polymer #4 CLR

InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
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Reference