2026-07-25_00000324|ligand|9W1A

Crystal structure of FGFR1 with a macrocyclic compound XS8148; X-ray diffraction 1.96Å
Protein #1 310 residues (99% resolved)

GPAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE

GPAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE
Non polymer #2 A1EUM

InChI=1S/C23H22N8O3/c1-29-3-4-33-5-6-34-22-17(16-11-26-30(2)13-16)9-20-24-12-19(31(20)28-22)14-7-15-10-25-27-21(15)18(8-14)23(29)32/h7-13H,3-6H2,1-2H3,(H,25,27)

Cn1cc(cn1)c2cc3ncc-4n3nc2OCCOCCN(C(=O)c5cc4cc6c5[nH]nc6)C
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Reference