2026-07-25_00000323
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ligand
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9W19
Crystal structure of FGFR2 with a macrocyclic compound XS8148;
X-ray diffraction 2.63Å
Protein #1
313 residues (95% resolved)
Raw Sequence ...
DTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE
Canonical Sequence ...
DTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE
Non polymer #2
A1EUM
InChI=1S/C23H22N8O3/c1-29-3-4-33-5-6-34-22-17(16-11-26-30(2)13-16)9-20-24-12-19(31(20)28-22)14-7-15-10-25-27-21(15)18(8-14)23(29)32/h7-13H,3-6H2,1-2H3,(H,25,27)
InChI=1S/C23H22N8O3/c1-29-3-4-33-5-6-34-22-17(16-11-26-30(2)13-16)9-20-24-12-19(31(20)28-22)14-7-15-10-25-27-21(15)18(8-14)23(29)32/h7-13H,3-6H2,1-2H3,(H,25,27)
SMILES: Cn1cc(cn1)c2cc3ncc-4n3nc2OCCOCCN(C(=O)c5cc4cc6c5[nH]nc6)C
Cn1cc(cn1)c2cc3ncc-4n3nc2OCCOCCN(C(=O)c5cc4cc6c5[nH]nc6)C
Biounit #1
monomer
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Biounit #2
monomer
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Model
Reference
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