2026-07-25_00000064|hard|32QS

Ternary complex of TRIM21 and BRD4 in complex with PROTAC 1b; X-ray diffraction 2.70Å
Protein #1 181 residues (92% resolved)

SMVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPL

SMVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPL
Protein #2 127 residues (99% resolved)

SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE

SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
Non polymer #3 A1KEC

InChI=1S/C45H44Cl2FN7O4S3/c1-27-28(2)61-45-41(27)42(29-9-12-32(46)13-10-29)52-37(43-53-51-26-55(43)45)23-40(56)50-18-7-5-6-8-20-54(25-31-17-19-49-24-36(31)47)44(57)35-15-11-30(21-39(35)62(4,58)59)34-16-14-33(48)22-38(34)60-3/h9-17,19,21-22,24,26,37H,5-8,18,20,23,25H2,1-4H3,(H,50,56)/t37-/m0/s1

Cc1c(sc-2c1C(=N[C@H](c3n2cnn3)CC(=O)NCCCCCCN(Cc4ccncc4Cl)C(=O)c5ccc(cc5S(=O)(=O)C)c6ccc(cc6SC)F)c7ccc(cc7)Cl)C
Non polymer #4 PEG

InChI=1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2

C(COCCO)O
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Reference