2026-07-25_00000060|ligand|32QN

Human TRIM21 PRYSPRY domain in complex with compound 29 (Z37); X-ray diffraction 1.80Å
Protein #1 181 residues (99% resolved)

SMVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPL

SMVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPL
Non polymer #2 A1KEF

InChI=1S/C23H28FNO4S2/c1-25(14-16-6-4-5-7-20(16)26)23(27)19-10-8-15(12-22(19)31(3,28)29)18-11-9-17(24)13-21(18)30-2/h8-13,16,20,26H,4-7,14H2,1-3H3/t16-,20+/m0/s1

CN(C[C@@H]1CCCC[C@H]1O)C(=O)c2ccc(cc2S(=O)(=O)C)c3ccc(cc3SC)F
Non polymer #3 EDO

InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

C(CO)O
Download coordinates
Reference