2026-07-25_00000017|hard|22ET

Cryo-EM structure of Retron Ec78 complex (cis); Electron microscopy 2.69Å
Protein #1 551 residues (100% resolved)

VTKQLERKAKGGSLLSAFELYQQEKNNNLHDLNNKSDQWFELCWNYLQQPAHDGNLDIYHPENQFCLRSMSFTDFRRFPQLDINFEEDLTIIIGNNGQGKTSILYAIAKTLSWFTANILKEDSSGQRLNEYSDIRNDSDNNFSDVSSNFFFGKGLKNISIRLSRSTLGASERRESIIKPAKEVADIWRIINERRMVNLPIFALYSVERSHPFSKPAKESIEKREDRFDAYNHALTGAGRFDHFVEWFIYLHKRAEAQGASAIELLEEQVNHLKQSVENGLTSMVPLLEETQKKLLTAQMRKESLQSVNMLTETAQMDIVSRAITTVVPSISRIWVETASGADIIKVTNDLQDVTIEQLSDGQRVFLALVADLARRMIMLNPLLKNPLEGRGIVLIAEIELHLHPKWQQEVIIVLRTVFPNIQFVITTHSPIVLSTTEIRCIREFKQNSESGELFLDSPPIQTKGSENSDILEQVMGVLSTPPNIAESYLVSNFEKSIIDDSEELSAESRRLYNKIISHFGQHSSELKKADSLIRLHRMKNKINKAKREKDS

VTKQLERKAKGGSLLSAFELYQQEKNNNLHDLNNKSDQWFELCWNYLQQPAHDGNLDIYHPENQFCLRSMSFTDFRRFPQLDINFEEDLTIIIGNNGQGKTSILYAIAKTLSWFTANILKEDSSGQRLNEYSDIRNDSDNNFSDVSSNFFFGKGLKNISIRLSRSTLGASERRESIIKPAKEVADIWRIINERRMVNLPIFALYSVERSHPFSKPAKESIEKREDRFDAYNHALTGAGRFDHFVEWFIYLHKRAEAQGASAIELLEEQVNHLKQSVENGLTSMVPLLEETQKKLLTAQMRKESLQSVNMLTETAQMDIVSRAITTVVPSISRIWVETASGADIIKVTNDLQDVTIEQLSDGQRVFLALVADLARRMIMLNPLLKNPLEGRGIVLIAEIELHLHPKWQQEVIIVLRTVFPNIQFVITTHSPIVLSTTEIRCIREFKQNSESGELFLDSPPIQTKGSENSDILEQVMGVLSTPPNIAESYLVSNFEKSIIDDSEELSAESRRLYNKIISHFGQHSSELKKADSLIRLHRMKNKINKAKREKDS
DNA #2 74 bases

(DG)(DG)(DA)(DA)(DG)(DC)(DG)(DA)(DA)(DA)(DG)(DT)(DG)(DT)(DC)(DG)(DC)(DA)(DA)(DC)(DC)(DT)(DG)(DA)(DG)(DG)(DG)(DA)(DG)(DG)(DA)(DA)(DC)(DG)(DA)(DG)(DT)(DG)(DA)(DG)(DG)(DG)(DT)(DT)(DG)(DC)(DG)(DA)(DC)(DA)(DC)(DT)(DT)(DT)(DC)(DG)(DC)(DA)(DA)(DC)(DC)(DC)(DT)(DA)(DA)(DA)(DT)(DA)(DC)(DG)(DT)(DT)(DC)(DA)

GGAAGCGAAAGTGTCGCAACCTGAGGGAGGAACGAGTGAGGGTTGCGACACTTTCGCAACCCTAAATACGTTCA
RNA #3 66 bases

ACUCUUUAGCGUUGGACGUUUUACGUCUAGUCGGGUGAUUAGCCAGACUCUAACUUAUUGAACGUA

ACUCUUUAGCGUUGGACGUUUUACGUCUAGUCGGGUGAUUAGCCAGACUCUAACUUAUUGAACGUA
Protein #4 310 residues (100% resolved)

MSVISSIATSLNQSELEVRAYLSDASGKYKVYRIPKRTTGFRIIAQPAKALKEYQRTFLQLYRFPIHECAMAYQKGKSIRDNALAHAHNRYLLKTDLEDFFNSITPDIFWRCVELSSVDVQLFLPEDRRYVDQILFWKPTKRSTRLVLSVGAPSSPIISNFCLYEFDKLIHEICRSLDIVYTRYADDLTFSCNVRDVLGSIPSMIETLLNKLFKKKLRLNRGKTIFSSMAHNRHVTGVTLNNEGKISLGRERKRFIKHLINQYRYGLIDESDKAYLVGLLAFANHIEPEFIIRMNNKYSTETMERLRRHL

MSVISSIATSLNQSELEVRAYLSDASGKYKVYRIPKRTTGFRIIAQPAKALKEYQRTFLQLYRFPIHECAMAYQKGKSIRDNALAHAHNRYLLKTDLEDFFNSITPDIFWRCVELSSVDVQLFLPEDRRYVDQILFWKPTKRSTRLVLSVGAPSSPIISNFCLYEFDKLIHEICRSLDIVYTRYADDLTFSCNVRDVLGSIPSMIETLLNKLFKKKLRLNRGKTIFSSMAHNRHVTGVTLNNEGKISLGRERKRFIKHLINQYRYGLIDESDKAYLVGLLAFANHIEPEFIIRMNNKYSTETMERLRRHL
Protein #5 215 residues (100% resolved)

MKSLNRTAGPAHLHQFRAGRDPWMSVEQSNIWPHLLEMQGEFCAYCECSLNRKHIEHFRPRGKFPALTFAWGNLFGSCGDSSKTGGWQRCGIFKDNGAGNYNPDHLIKPDDDNPDDYLLFLTTGHVVPAKDISGTKLLKAQETIRVFNLNGDPSLLGSRKKALNYIMEEVILLHESYEDLGDALWHEMRDAEIQEIGNKEFYTALKHAWLHNSEY

MKSLNRTAGPAHLHQFRAGRDPWMSVEQSNIWPHLLEMQGEFCAYCECSLNRKHIEHFRPRGKFPALTFAWGNLFGSCGDSSKTGGWQRCGIFKDNGAGNYNPDHLIKPDDDNPDDYLLFLTTGHVVPAKDISGTKLLKAQETIRVFNLNGDPSLLGSRKKALNYIMEEVILLHESYEDLGDALWHEMRDAEIQEIGNKEFYTALKHAWLHNSEY
Non polymer #6 ADP

InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
Non polymer #7 ATP

InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N
Non polymer #8 ZN

InChI=1S/Zn/q+2

[Zn+2]
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Reference