2026-07-11_00000286|hard|9Z7V

Cryo-EM Structure of the Type III-Bv CRISPR Complex from Dissulfurispira thermophila bound to target RNA with complementary PFS; Electron microscopy 3.00Å
Protein #1 612 residues (97% resolved)

MGHHHHHHLEVLFQGPMENKFLFLFTITPVQSFINQARKAQDLYAGSFMLSHFSKAAANKLKMEFDCEIIFPDIANNSIPNRFAAVVNVNENEAQAVGDSLQKAVEAEIKRIGDSVINGLKINKPNGFDEQLSSYFTVSYLFVPYNEDDYKQCYSELESLMGAIKSVRAFSQYPDSERGRKCSICGERNVKFYRMAENEKDIERIKKLKLFSNDVYAVKNSDYRELGPRYLQAGEGLCGVCFTKRGLDRAGIPEYKAKFPSTSKIALFDAFKQLREKRGDLGTIIDSDNYEPQGIFALKNNKNLDDFPELSEMEKKNTRELYEAMEDYKISYSPYYAVMLFDGDSMGEWLSGNKIKDEKLKEFHKELTKKLGEFANAVRDTIKEPLGVTVYAGGEDFLGFFNIKYLLEGMKHLRNKFNELVNLPLKDFYADNTYNMTFSAGAVIAHIKTPLSEVLNWARKVEQEAKDIDDTKDAFAIAVLKHSGEIEKTVFKWRVNDTYTTDLMSKIVTEINNDRLSNTFIKKLNQELIKLLDKDGNYRDDNIIKAEIKRLLMRSFMKTKDEDEDAFKKRKAETAKELQLHNLLIHSNGVRNFLNFLNITDFIARQAKGGAA

MGHHHHHHLEVLFQGPMENKFLFLFTITPVQSFINQARKAQDLYAGSFMLSHFSKAAANKLKMEFDCEIIFPDIANNSIPNRFAAVVNVNENEAQAVGDSLQKAVEAEIKRIGDSVINGLKINKPNGFDEQLSSYFTVSYLFVPYNEDDYKQCYSELESLMGAIKSVRAFSQYPDSERGRKCSICGERNVKFYRMAENEKDIERIKKLKLFSNDVYAVKNSDYRELGPRYLQAGEGLCGVCFTKRGLDRAGIPEYKAKFPSTSKIALFDAFKQLREKRGDLGTIIDSDNYEPQGIFALKNNKNLDDFPELSEMEKKNTRELYEAMEDYKISYSPYYAVMLFDGDSMGEWLSGNKIKDEKLKEFHKELTKKLGEFANAVRDTIKEPLGVTVYAGGEDFLGFFNIKYLLEGMKHLRNKFNELVNLPLKDFYADNTYNMTFSAGAVIAHIKTPLSEVLNWARKVEQEAKDIDDTKDAFAIAVLKHSGEIEKTVFKWRVNDTYTTDLMSKIVTEINNDRLSNTFIKKLNQELIKLLDKDGNYRDDNIIKAEIKRLLMRSFMKTKDEDEDAFKKRKAETAKELQLHNLLIHSNGVRNFLNFLNITDFIARQAKGGAA
Protein #2 360 residues (100% resolved)

MKRITINALDVLFLRDGKPFTMGSDTWGSGISLPYPSMIYGVLRSLYFSHNISMLKHAAPIDELNHNDPTRNLKIKGIYLKRASDLLFPVPMDCVVLKNSRDEKLIPLMPVKAQCISNCKTSAVLRPEKGEQIESAEDGWIDKAAMEEYLNGIYENMSYSKLSDFVLSEAKIGIARNNKTHIAEDSMLYRVGMKRLKDTTIVVDIDGLEIPDAGIIKIGGEGRPASFKAIDIDETSILQPAINSNKIEKIKLYIATPAIFKKGWLPQTIDDRDLEGEINGIGLKLITAAIGRPLYVGGFDIKKGPKPMKRAVPAGSVYYFEIHGQYSNEQIINALHDKAISDREQDRQQGFGIAYVGKWE

MKRITINALDVLFLRDGKPFTMGSDTWGSGISLPYPSMIYGVLRSLYFSHNISMLKHAAPIDELNHNDPTRNLKIKGIYLKRASDLLFPVPMDCVVLKNSRDEKLIPLMPVKAQCISNCKTSAVLRPEKGEQIESAEDGWIDKAAMEEYLNGIYENMSYSKLSDFVLSEAKIGIARNNKTHIAEDSMLYRVGMKRLKDTTIVVDIDGLEIPDAGIIKIGGEGRPASFKAIDIDETSILQPAINSNKIEKIKLYIATPAIFKKGWLPQTIDDRDLEGEINGIGLKLITAAIGRPLYVGGFDIKKGPKPMKRAVPAGSVYYFEIHGQYSNEQIINALHDKAISDREQDRQQGFGIAYVGKWE
Protein #3 315 residues (100% resolved)

MFKKARPFFIICETPLHCGSGNDIGNVDLPIQRERHTDFPKIEASSLKGGIREAFEEADKDIKVGSLTINISDKSTISLAFGPEQGSDHAGALGFTDARILLFPVKSMKGVFAWVTCPQVLERFKSDLNLCGVNLGFEMPQANTAPKDCSLFINGNKIVLEEYTFEIARDRDESGNCTSLANWLSENLFLANSGIQFWKEKIKKDIVVISDDEFRDFVTLSTEVITRTKINNETGTVQSGALFTEEYLPTDTVLYSLALTTPVFKEKDEEKGIFKQDSANEEDMVMEFFTTGLPEIIQLGGNATIGKGIARVKIL

MFKKARPFFIICETPLHCGSGNDIGNVDLPIQRERHTDFPKIEASSLKGGIREAFEEADKDIKVGSLTINISDKSTISLAFGPEQGSDHAGALGFTDARILLFPVKSMKGVFAWVTCPQVLERFKSDLNLCGVNLGFEMPQANTAPKDCSLFINGNKIVLEEYTFEIARDRDESGNCTSLANWLSENLFLANSGIQFWKEKIKKDIVVISDDEFRDFVTLSTEVITRTKINNETGTVQSGALFTEEYLPTDTVLYSLALTTPVFKEKDEEKGIFKQDSANEEDMVMEFFTTGLPEIIQLGGNATIGKGIARVKIL
Protein #4 140 residues (96% resolved)

MTDNNLTIQKSIERQRAAFAYKCAEAGKSITKSKEYKAYVKNIPMLIKTNGIGATFAFVKAKSEADVDKSGYAYKLIYEQTTEWLKQEPKGLIYEKLNNTDMVKALVELDSDKYRAVTNEVLALFVWLKRFAEGLIEGEK

MTDNNLTIQKSIERQRAAFAYKCAEAGKSITKSKEYKAYVKNIPMLIKTNGIGATFAFVKAKSEADVDKSGYAYKLIYEQTTEWLKQEPKGLIYEKLNNTDMVKALVELDSDKYRAVTNEVLALFVWLKRFAEGLIEGEK
Protein #5 376 residues (79% resolved)

MSEKGKIKTFKKAKGFGFIKYSGGEIFFHINDVIASDSDKIKEGIDVEFEIGKGKEGKPAAKKIKVKSLYRQQNIPINDDISGINYFLPKDTYAAVKPEQIDNFNLLLNKIPYFDGKKFNFYKKDKKRNEILNLARRFNYNASFIKRLSERHKNSISQLLGSGSITSTTLSPDWRFIIGIGNESVYETSITLHHIYGIPYIPGQAVKGVVRSWIITEVFGQDEKKALKDALFCHIFGSPKESAIGEHQGSVIFFDALPITLPQLEVDVMNPHYGDYYQGKEKSNKPVPPADYLNPNPIPFLTVGKDTKFEFTVGMKKLKQAREVLKNGSSRLISECEGLTAEKNLHEIAISWLKKALTEHGIGAKTAVGYGYFEKT

MSEKGKIKTFKKAKGFGFIKYSGGEIFFHINDVIASDSDKIKEGIDVEFEIGKGKEGKPAAKKIKVKSLYRQQNIPINDDISGINYFLPKDTYAAVKPEQIDNFNLLLNKIPYFDGKKFNFYKKDKKRNEILNLARRFNYNASFIKRLSERHKNSISQLLGSGSITSTTLSPDWRFIIGIGNESVYETSITLHHIYGIPYIPGQAVKGVVRSWIITEVFGQDEKKALKDALFCHIFGSPKESAIGEHQGSVIFFDALPITLPQLEVDVMNPHYGDYYQGKEKSNKPVPPADYLNPNPIPFLTVGKDTKFEFTVGMKKLKQAREVLKNGSSRLISECEGLTAEKNLHEIAISWLKKALTEHGIGAKTAVGYGYFEKT
RNA #6 36 bases

UCUAACUUUACUCAGUUCGUUCUCGUCGACCUUUCU

UCUAACUUUACUCAGUUCGUUCUCGUCGACCUUUCU
RNA #7 38 bases

ACUGAAACGUCGACGAGAACGAACUGAGUAAAGUUAGA

ACUGAAACGUCGACGAGAACGAACUGAGUAAAGUUAGA
Protein #8 438 residues (74% resolved)

MKTVGFTLTTITPMFLSGIDSRTPELRAPSIKGAMRFWWRALKAEPDIDKLRKKEDQIFGSSDEKIGRAKFSIRVSQIDKKSPSTYKNPDKYDPVGYHFYSVFMEGGRERYYSPEENRFKIILTSQDEGILKIASASLWALVYLGAIGTRARRGAGNMAIISVDDADKILDDTGLDFIPKGNNSEEVAKWIRDNCNTAKAIINKDKTTFVSEYSNLCFSRFVIGNQPFKSWKDALGAAGFKAFRDKNKSRILETPSFGFPVRHRTNNINNITVTGRVGKDSFSRRSSPIIFKIIKSGSYYYWMVLRLSGEFLPEGGVIKANNNTQKPDYSIIDEFWAELKKRGVEHILSMPDTLMTIIDKLKKDIDPQKIILFGSKARGDFHSRSDTDIAVETDKSLEELLLNGAVDIVDMNRANDELKDKIKKEGVVIYERKGEEAS

MKTVGFTLTTITPMFLSGIDSRTPELRAPSIKGAMRFWWRALKAEPDIDKLRKKEDQIFGSSDEKIGRAKFSIRVSQIDKKSPSTYKNPDKYDPVGYHFYSVFMEGGRERYYSPEENRFKIILTSQDEGILKIASASLWALVYLGAIGTRARRGAGNMAIISVDDADKILDDTGLDFIPKGNNSEEVAKWIRDNCNTAKAIINKDKTTFVSEYSNLCFSRFVIGNQPFKSWKDALGAAGFKAFRDKNKSRILETPSFGFPVRHRTNNINNITVTGRVGKDSFSRRSSPIIFKIIKSGSYYYWMVLRLSGEFLPEGGVIKANNNTQKPDYSIIDEFWAELKKRGVEHILSMPDTLMTIIDKLKKDIDPQKIILFGSKARGDFHSRSDTDIAVETDKSLEELLLNGAVDIVDMNRANDELKDKIKKEGVVIYERKGEEAS
Non polymer #9 ZN

InChI=1S/Zn/q+2

[Zn+2]
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Reference