2026-07-11_00000285|hard|9Z7Q

Cryo-EM Structure of the Type III-Bv CRISPR Complex from Dissulfurispira thermophila bound to a crRNA; Electron microscopy 3.00Å
Protein #1 612 residues (97% resolved)

MGHHHHHHLEVLFQGPMENKFLFLFTITPVQSFINQARKAQDLYAGSFMLSHFSKAAANKLKMEFDCEIIFPDIANNSIPNRFAAVVNVNENEAQAVGDSLQKAVEAEIKRIGDSVINGLKINKPNGFDEQLSSYFTVSYLFVPYNEDDYKQCYSELESLMGAIKSVRAFSQYPDSERGRKCSICGERNVKFYRMAENEKDIERIKKLKLFSNDVYAVKNSDYRELGPRYLQAGEGLCGVCFTKRGLDRAGIPEYKAKFPSTSKIALFDAFKQLREKRGDLGTIIDSDNYEPQGIFALKNNKNLDDFPELSEMEKKNTRELYEAMEDYKISYSPYYAVMLFDGDSMGEWLSGNKIKDEKLKEFHKELTKKLGEFANAVRDTIKEPLGVTVYAGGEDFLGFFNIKYLLEGMKHLRNKFNELVNLPLKDFYADNTYNMTFSAGAVIAHIKTPLSEVLNWARKVEQEAKDIDDTKDAFAIAVLKHSGEIEKTVFKWRVNDTYTTDLMSKIVTEINNDRLSNTFIKKLNQELIKLLDKDGNYRDDNIIKAEIKRLLMRSFMKTKDEDEDAFKKRKAETAKELQLHNLLIHSNGVRNFLNFLNITDFIARQAKGGAA

MGHHHHHHLEVLFQGPMENKFLFLFTITPVQSFINQARKAQDLYAGSFMLSHFSKAAANKLKMEFDCEIIFPDIANNSIPNRFAAVVNVNENEAQAVGDSLQKAVEAEIKRIGDSVINGLKINKPNGFDEQLSSYFTVSYLFVPYNEDDYKQCYSELESLMGAIKSVRAFSQYPDSERGRKCSICGERNVKFYRMAENEKDIERIKKLKLFSNDVYAVKNSDYRELGPRYLQAGEGLCGVCFTKRGLDRAGIPEYKAKFPSTSKIALFDAFKQLREKRGDLGTIIDSDNYEPQGIFALKNNKNLDDFPELSEMEKKNTRELYEAMEDYKISYSPYYAVMLFDGDSMGEWLSGNKIKDEKLKEFHKELTKKLGEFANAVRDTIKEPLGVTVYAGGEDFLGFFNIKYLLEGMKHLRNKFNELVNLPLKDFYADNTYNMTFSAGAVIAHIKTPLSEVLNWARKVEQEAKDIDDTKDAFAIAVLKHSGEIEKTVFKWRVNDTYTTDLMSKIVTEINNDRLSNTFIKKLNQELIKLLDKDGNYRDDNIIKAEIKRLLMRSFMKTKDEDEDAFKKRKAETAKELQLHNLLIHSNGVRNFLNFLNITDFIARQAKGGAA
Protein #2 360 residues (100% resolved)

MKRITINALDVLFLRDGKPFTMGSDTWGSGISLPYPSMIYGVLRSLYFSHNISMLKHAAPIDELNHNDPTRNLKIKGIYLKRASDLLFPVPMDCVVLKNSRDEKLIPLMPVKAQCISNCKTSAVLRPEKGEQIESAEDGWIDKAAMEEYLNGIYENMSYSKLSDFVLSEAKIGIARNNKTHIAEDSMLYRVGMKRLKDTTIVVDIDGLEIPDAGIIKIGGEGRPASFKAIDIDETSILQPAINSNKIEKIKLYIATPAIFKKGWLPQTIDDRDLEGEINGIGLKLITAAIGRPLYVGGFDIKKGPKPMKRAVPAGSVYYFEIHGQYSNEQIINALHDKAISDREQDRQQGFGIAYVGKWE

MKRITINALDVLFLRDGKPFTMGSDTWGSGISLPYPSMIYGVLRSLYFSHNISMLKHAAPIDELNHNDPTRNLKIKGIYLKRASDLLFPVPMDCVVLKNSRDEKLIPLMPVKAQCISNCKTSAVLRPEKGEQIESAEDGWIDKAAMEEYLNGIYENMSYSKLSDFVLSEAKIGIARNNKTHIAEDSMLYRVGMKRLKDTTIVVDIDGLEIPDAGIIKIGGEGRPASFKAIDIDETSILQPAINSNKIEKIKLYIATPAIFKKGWLPQTIDDRDLEGEINGIGLKLITAAIGRPLYVGGFDIKKGPKPMKRAVPAGSVYYFEIHGQYSNEQIINALHDKAISDREQDRQQGFGIAYVGKWE
Protein #3 315 residues (100% resolved)

MFKKARPFFIICETPLHCGSGNDIGNVDLPIQRERHTDFPKIEASSLKGGIREAFEEADKDIKVGSLTINISDKSTISLAFGPEQGSDHAGALGFTDARILLFPVKSMKGVFAWVTCPQVLERFKSDLNLCGVNLGFEMPQANTAPKDCSLFINGNKIVLEEYTFEIARDRDESGNCTSLANWLSENLFLANSGIQFWKEKIKKDIVVISDDEFRDFVTLSTEVITRTKINNETGTVQSGALFTEEYLPTDTVLYSLALTTPVFKEKDEEKGIFKQDSANEEDMVMEFFTTGLPEIIQLGGNATIGKGIARVKIL

MFKKARPFFIICETPLHCGSGNDIGNVDLPIQRERHTDFPKIEASSLKGGIREAFEEADKDIKVGSLTINISDKSTISLAFGPEQGSDHAGALGFTDARILLFPVKSMKGVFAWVTCPQVLERFKSDLNLCGVNLGFEMPQANTAPKDCSLFINGNKIVLEEYTFEIARDRDESGNCTSLANWLSENLFLANSGIQFWKEKIKKDIVVISDDEFRDFVTLSTEVITRTKINNETGTVQSGALFTEEYLPTDTVLYSLALTTPVFKEKDEEKGIFKQDSANEEDMVMEFFTTGLPEIIQLGGNATIGKGIARVKIL
Protein #4 140 residues (96% resolved)

MTDNNLTIQKSIERQRAAFAYKCAEAGKSITKSKEYKAYVKNIPMLIKTNGIGATFAFVKAKSEADVDKSGYAYKLIYEQTTEWLKQEPKGLIYEKLNNTDMVKALVELDSDKYRAVTNEVLALFVWLKRFAEGLIEGEK

MTDNNLTIQKSIERQRAAFAYKCAEAGKSITKSKEYKAYVKNIPMLIKTNGIGATFAFVKAKSEADVDKSGYAYKLIYEQTTEWLKQEPKGLIYEKLNNTDMVKALVELDSDKYRAVTNEVLALFVWLKRFAEGLIEGEK
Protein #5 376 residues (80% resolved)

MSEKGKIKTFKKAKGFGFIKYSGGEIFFHINDVIASDSDKIKEGIDVEFEIGKGKEGKPAAKKIKVKSLYRQQNIPINDDISGINYFLPKDTYAAVKPEQIDNFNLLLNKIPYFDGKKFNFYKKDKKRNEILNLARRFNYNASFIKRLSERHKNSISQLLGSGSITSTTLSPDWRFIIGIGNESVYETSITLHHIYGIPYIPGQAVKGVVRSWIITEVFGQDEKKALKDALFCHIFGSPKESAIGEHQGSVIFFDALPITLPQLEVDVMNPHYGDYYQGKEKSNKPVPPADYLNPNPIPFLTVGKDTKFEFTVGMKKLKQAREVLKNGSSRLISECEGLTAEKNLHEIAISWLKKALTEHGIGAKTAVGYGYFEKT

MSEKGKIKTFKKAKGFGFIKYSGGEIFFHINDVIASDSDKIKEGIDVEFEIGKGKEGKPAAKKIKVKSLYRQQNIPINDDISGINYFLPKDTYAAVKPEQIDNFNLLLNKIPYFDGKKFNFYKKDKKRNEILNLARRFNYNASFIKRLSERHKNSISQLLGSGSITSTTLSPDWRFIIGIGNESVYETSITLHHIYGIPYIPGQAVKGVVRSWIITEVFGQDEKKALKDALFCHIFGSPKESAIGEHQGSVIFFDALPITLPQLEVDVMNPHYGDYYQGKEKSNKPVPPADYLNPNPIPFLTVGKDTKFEFTVGMKKLKQAREVLKNGSSRLISECEGLTAEKNLHEIAISWLKKALTEHGIGAKTAVGYGYFEKT
RNA #6 38 bases

ACUGAAACGUCUGGAAGUUUGCAGCUGGAUACGACACA

ACUGAAACGUCUGGAAGUUUGCAGCUGGAUACGACACA
Protein #7 438 residues (78% resolved)

MKTVGFTLTTITPMFLSGIDSRTPELRAPSIKGAMRFWWRALKAEPDIDKLRKKEDQIFGSSDEKIGRAKFSIRVSQIDKKSPSTYKNPDKYDPVGYHFYSVFMEGGRERYYSPEENRFKIILTSQDEGILKIASASLWALVYLGAIGTRARRGAGNMAIISVDDADKILDDTGLDFIPKGNNSEEVAKWIRDNCNTAKAIINKDKTTFVSEYSNLCFSRFVIGNQPFKSWKDALGAAGFKAFRDKNKSRILETPSFGFPVRHRTNNINNITVTGRVGKDSFSRRSSPIIFKIIKSGSYYYWMVLRLSGEFLPEGGVIKANNNTQKPDYSIIDEFWAELKKRGVEHILSMPDTLMTIIDKLKKDIDPQKIILFGSKARGDFHSRSDTDIAVETDKSLEELLLNGAVDIVDMNRANDELKDKIKKEGVVIYERKGEEAS

MKTVGFTLTTITPMFLSGIDSRTPELRAPSIKGAMRFWWRALKAEPDIDKLRKKEDQIFGSSDEKIGRAKFSIRVSQIDKKSPSTYKNPDKYDPVGYHFYSVFMEGGRERYYSPEENRFKIILTSQDEGILKIASASLWALVYLGAIGTRARRGAGNMAIISVDDADKILDDTGLDFIPKGNNSEEVAKWIRDNCNTAKAIINKDKTTFVSEYSNLCFSRFVIGNQPFKSWKDALGAAGFKAFRDKNKSRILETPSFGFPVRHRTNNINNITVTGRVGKDSFSRRSSPIIFKIIKSGSYYYWMVLRLSGEFLPEGGVIKANNNTQKPDYSIIDEFWAELKKRGVEHILSMPDTLMTIIDKLKKDIDPQKIILFGSKARGDFHSRSDTDIAVETDKSLEELLLNGAVDIVDMNRANDELKDKIKKEGVVIYERKGEEAS
Non polymer #8 ZN

InChI=1S/Zn/q+2

[Zn+2]
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Reference