2026-06-27_00000282|hard|9Z5U

Cryo-EM structure of a soluble HCV E1E2 antigen in complex with AT1211 fab; Electron microscopy 3.06Å
Protein #1 589 residues (34% resolved)

YQVRNSTGLYHVTNDCPNSSIVYETADAILHTPGCVPCVREGNASRCWVPMTCTVATRDGKLPATQLRRGGSGGSGGSPRRHWTTQDCNCSIYPGHVTGHRMAWDMMMNPSPTTALVVAQLLRIPQAILDMIAPGGRIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNYRRRRRRQTYVTGGTAARATSGLANFFSPGAKQDVQLINTNGSWHINRTALNCNTSLETGWIAGLIYLNKFNSSGCPERMASCRPLADFAQGWGPISYANGSGPDHRPYCWHYPPKPCGIVSAKSVCGPVYCFTPSPVVVGTTNKLGAPTYSWGENETDVFVLNNTRPPLGNWFGCTWMNSTGFTKVCGAPPCAIGGVGNNTLHCPTDCFRKHPEATYSRCGSGPWITPRCLVDYPYRLWHYPCTANYTRFKVRMYIGGVEHRLDAACNWTRGERCDLEDRDRSELSPLLLSTTQWQVLPCSFTTPPALSCGLIHLHQNIVDVQYLYGVGSSIVSWAIPGGLTDTLQAETDQLEDKKSALQTEIANLLKEKEKLEFILAAYGGSAWSHPQFEKGGGSGGGSGGSSAWSHPQFEK

YQVRNSTGLYHVTNDCPNSSIVYETADAILHTPGCVPCVREGNASRCWVPMTCTVATRDGKLPATQLRRGGSGGSGGSPRRHWTTQDCNCSIYPGHVTGHRMAWDMMMNPSPTTALVVAQLLRIPQAILDMIAPGGRIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNYRRRRRRQTYVTGGTAARATSGLANFFSPGAKQDVQLINTNGSWHINRTALNCNTSLETGWIAGLIYLNKFNSSGCPERMASCRPLADFAQGWGPISYANGSGPDHRPYCWHYPPKPCGIVSAKSVCGPVYCFTPSPVVVGTTNKLGAPTYSWGENETDVFVLNNTRPPLGNWFGCTWMNSTGFTKVCGAPPCAIGGVGNNTLHCPTDCFRKHPEATYSRCGSGPWITPRCLVDYPYRLWHYPCTANYTRFKVRMYIGGVEHRLDAACNWTRGERCDLEDRDRSELSPLLLSTTQWQVLPCSFTTPPALSCGLIHLHQNIVDVQYLYGVGSSIVSWAIPGGLTDTLQAETDQLEDKKSALQTEIANLLKEKEKLEFILAAYGGSAWSHPQFEKGGGSGGGSGGSSAWSHPQFEK
Protein #2 229 residues (50% resolved)

QVQLVQSGAEVKKPGSSVKVSCKASGGTFSGYGITWVRQAPGQGLEWMGTIIPVSATETYAQRLQGRVTISADEHSTTSYMEVSSLKSEDTALYYCARHDYFWGTPLDIWGQGTMVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCHHHHHH

QVQLVQSGAEVKKPGSSVKVSCKASGGTFSGYGITWVRQAPGQGLEWMGTIIPVSATETYAQRLQGRVTISADEHSTTSYMEVSSLKSEDTALYYCARHDYFWGTPLDIWGQGTMVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCHHHHHH
Protein #3 214 residues (49% resolved)

EIVLTQSPDFQSVTPKEKVTITCRASQSIGSNLHWYQQKPGQSPKLLIKYASQSFSGVPSRFSGSGSGTDFTLTINSLEAEDAATYFCHQSYNLPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTRSFNRGEC

EIVLTQSPDFQSVTPKEKVTITCRASQSIGSNLHWYQQKPGQSPKLLIKYASQSFSGVPSRFSGSGSGTDFTLTINSLEAEDAATYFCHQSYNLPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTRSFNRGEC
Non polymer #4 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

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Reference