2026-06-27_00000208|ligand|9VLE

hAGO2-MID in complex with a chemical modified uridine monophosphate; X-ray diffraction 1.99Å

Protein #1 137 residues (99% resolved)

Raw Sequence ...

KQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVQQ

Canonical Sequence ...

KQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVQQ

Non polymer #2 A1ESM

InChI=1S/C19H22N3O12P/c23-13(5-9-1-3-10(4-2-9)6-14(24)25)20-11-7-22(19(29)21-17(11)28)18-16(27)15(26)12(34-18)8-33-35(30,31)32/h1-4,7,12,15-16,18,26-27H,5-6,8H2,(H,20,23)(H,24,25)(H,21,28,29)(H2,30,31,32)/t12-,15-,16-,18-/m1/s1

InChI=1S/C19H22N3O12P/c23-13(5-9-1-3-10(4-2-9)6-14(24)25)20-11-7-22(19(29)21-17(11)28)18-16(27)15(26)12(34-18)8-33-35(30,31)32/h1-4,7,12,15-16,18,26-27H,5-6,8H2,(H,20,23)(H,24,25)(H,21,28,29)(H2,30,31,32)/t12-,15-,16-,18-/m1/s1

SMILES: c1cc(ccc1CC(=O)NC2=CN(C(=O)NC2=O)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)CC(=O)O

c1cc(ccc1CC(=O)NC2=CN(C(=O)NC2=O)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)CC(=O)O

Biounit #1 monomer

Biounit #2 monomer

Biounit #3 monomer

Reference