2026-06-27_00000207|ligand|9VLD

hAGO2-MID in complex with a chemical modified uridine monophosphate; X-ray diffraction 2.05Å

Protein #1 135 residues (100% resolved)

Raw Sequence ...

KQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGV

Canonical Sequence ...

KQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGV

Non polymer #2 A1ESL

InChI=1S/C18H21N2O11P/c21-13(22)6-3-9-1-4-10(5-2-9)11-7-20(18(26)19-16(11)25)17-15(24)14(23)12(31-17)8-30-32(27,28)29/h1-2,4-5,7,12,14-15,17,23-24H,3,6,8H2,(H,21,22)(H,19,25,26)(H2,27,28,29)/t12-,14-,15-,17-/m1/s1

InChI=1S/C18H21N2O11P/c21-13(22)6-3-9-1-4-10(5-2-9)11-7-20(18(26)19-16(11)25)17-15(24)14(23)12(31-17)8-30-32(27,28)29/h1-2,4-5,7,12,14-15,17,23-24H,3,6,8H2,(H,21,22)(H,19,25,26)(H2,27,28,29)/t12-,14-,15-,17-/m1/s1

SMILES: c1cc(ccc1CCC(=O)O)C2=CN(C(=O)NC2=O)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O

c1cc(ccc1CCC(=O)O)C2=CN(C(=O)NC2=O)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O

Non polymer #3 PO4

InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3

SMILES: [O-]P(=O)([O-])[O-]

[O-]P(=O)([O-])[O-]

Biounit #1 monomer

Biounit #2 monomer

Biounit #3 monomer

Reference