2026-06-27_00000206|ligand|9VLC

hAGO2-MID in complex with a chemical modified uridine monophosphate; X-ray diffraction 2.09Å

Protein #1 135 residues (100% resolved)

Raw Sequence ...

KQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGV

Canonical Sequence ...

KQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGV

Non polymer #2 A1ESK

InChI=1S/C18H21N2O11P/c21-13(22)5-4-9-2-1-3-10(6-9)11-7-20(18(26)19-16(11)25)17-15(24)14(23)12(31-17)8-30-32(27,28)29/h1-3,6-7,12,14-15,17,23-24H,4-5,8H2,(H,21,22)(H,19,25,26)(H2,27,28,29)/t12-,14-,15-,17-/m1/s1

InChI=1S/C18H21N2O11P/c21-13(22)5-4-9-2-1-3-10(6-9)11-7-20(18(26)19-16(11)25)17-15(24)14(23)12(31-17)8-30-32(27,28)29/h1-3,6-7,12,14-15,17,23-24H,4-5,8H2,(H,21,22)(H,19,25,26)(H2,27,28,29)/t12-,14-,15-,17-/m1/s1

SMILES: c1cc(cc(c1)C2=CN(C(=O)NC2=O)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)CCC(=O)O

c1cc(cc(c1)C2=CN(C(=O)NC2=O)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)CCC(=O)O

Biounit #1 monomer

Biounit #2 monomer

Biounit #3 monomer

Reference