2026-06-27_00000104|hard|9MSK

Structure of hepatitis C virus envelope glycoprotein E2 core from isolate H77 bound to neutralizing antibody RM3-26; X-ray diffraction 2.23Å
Protein #1 223 residues (100% resolved)

QLQLQESGPGLVKPSETLSLTCIVSGGSISGYSWNWIRQPPGKGLEWIGNIFSGGDDANYNPSLKSRVTLSVDTSKNHFSLRLSSVTAADTAVYYCARHSAGFITGRYFELWGQGALVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK

QLQLQESGPGLVKPSETLSLTCIVSGGSISGYSWNWIRQPPGKGLEWIGNIFSGGDDANYNPSLKSRVTLSVDTSKNHFSLRLSSVTAADTAVYYCARHSAGFITGRYFELWGQGALVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
Protein #2 212 residues (100% resolved)

DIQMTQSPSSLSASLGDRVTITCRANQDISSSLAWYQQKPGKAPKPLIYYASNLESGVPSRFRGSGSGTEFTLTISSLQSEDFAVYYCQQYNSDPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPIEAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTQGTTSVTKSFNRGEC

DIQMTQSPSSLSASLGDRVTITCRANQDISSSLAWYQQKPGKAPKPLIYYASNLESGVPSRFRGSGSGTEFTLTISSLQSEDFAVYYCQQYNSDPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPIEAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTQGTTSVTKSFNRGEC
Protein #3 191 residues (46% resolved)

ARQLINTNGSWHINSTALNCNESLNTGWLAGLFYQHKFDSSGCPERLASCGSSGCWHYPPRPCGIVPAKSVCGPVYCFTPSPVVVGTTDRSGAPTYSWGANDTDVFVLNNTRPPLGNWFGCTWMNSTGFTKVCGAPPGGPTDGGSGPWITPRCMVDYPYRLWHYPCTINYTIFKVRMYVGGVEHRLEAACN

ARQLINTNGSWHINSTALNCNESLNTGWLAGLFYQHKFDSSGCPERLASCGSSGCWHYPPRPCGIVPAKSVCGPVYCFTPSPVVVGTTDRSGAPTYSWGANDTDVFVLNNTRPPLGNWFGCTWMNSTGFTKVCGAPPGGPTDGGSGPWITPRCMVDYPYRLWHYPCTINYTIFKVRMYVGGVEHRLEAACN
Non polymer #4 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
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