2026-06-13_00000292
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ligand
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9YKO
Crystal structure of human DYRK1A kinase bound with inhibitor FC3;
X-ray diffraction 2.77Å
Protein #1
359 residues (96% resolved)
Raw Sequence ...
SSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQ(PTR)IQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE
Canonical Sequence ...
SSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE
Non polymer #2
A1CXN
InChI=1S/C14H9NO5S/c16-8-2-1-6(3-9(8)17)13(20)14-15-7-4-10(18)11(19)5-12(7)21-14/h1-5,16-19H
InChI=1S/C14H9NO5S/c16-8-2-1-6(3-9(8)17)13(20)14-15-7-4-10(18)11(19)5-12(7)21-14/h1-5,16-19H
SMILES: c1cc(c(cc1C(=O)c2nc3cc(c(cc3s2)O)O)O)O
c1cc(c(cc1C(=O)c2nc3cc(c(cc3s2)O)O)O)O
Biounit #1
monomer
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Biounit #2
monomer
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Biounit #3
monomer
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Biounit #4
monomer
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Model
Reference
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