2026-06-13_00000281|medium|9WG4

Cryo-EM structure of pocket engineered OR52cs in its active state; Electron microscopy 3.29Å
Protein #1 130 residues (96% resolved)

VQLQESGGGLVQPGGSLRLSCAASGFTFSNYKMNWVRQAPGKGLEWVSDISQSGASISYTGSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCARCPAPFTRDCFDVTSTTYAYRGQGTQVTVHHHHH

VQLQESGGGLVQPGGSLRLSCAASGFTFSNYKMNWVRQAPGKGLEWVSDISQSGASISYTGSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCARCPAPFTRDCFDVTSTTYAYRGQGTQVTVHHHHH
Protein #2 323 residues (88% resolved)

DYKDDDDAIDMPTSNHTSFHPSSFLLVGIPGLESVHIWISIPFCAMYLIALLGNSTLLFVIKTERSLHEPMYYFLAMLAATDLVLSTSTIPKMLAIFWFNLKEISFDACLTQMFFIHSFTAMESGVLLAMAFDRYVAICYPLRYTTILTNKVIGKIGMAVVLRAVLLVIPLPFLLKRLPFCGTNIIPHTYCEHMGVAKLACADIKVNIIYGLFNILLLVGLDVILIALSYVLILRAVFRLPSQDARLKALSTCGSHICVILAFYTPAFFSFLTHRFGHHIPPYIHILLANLYLLVPPMLNPIIYGVKTKQIRERVLKIFFKKK

DYKDDDDAIDMPTSNHTSFHPSSFLLVGIPGLESVHIWISIPFCAMYLIALLGNSTLLFVIKTERSLHEPMYYFLAMLAATDLVLSTSTIPKMLAIFWFNLKEISFDACLTQMFFIHSFTAMESGVLLAMAFDRYVAICYPLRYTTILTNKVIGKIGMAVVLRAVLLVIPLPFLLKRLPFCGTNIIPHTYCEHMGVAKLACADIKVNIIYGLFNILLLVGLDVILIALSYVLILRAVFRLPSQDARLKALSTCGSHICVILAFYTPAFFSFLTHRFGHHIPPYIHILLANLYLLVPPMLNPIIYGVKTKQIRERVLKIFFKKK
Protein #3 248 residues (88% resolved)

NSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGADNSGKSTIVKQMRILHGGSGGSGGTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVDSSDYNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENARRIFNDCRDIIQRMHLRQYELL

NSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGADNSGKSTIVKQMRILHGGSGGSGGTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVDSSDYNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENARRIFNDCRDIIQRMHLRQYELL
Protein #4 358 residues (94% resolved)

MHHHHHHLEVLFQGPGSSGSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

MHHHHHHLEVLFQGPGSSGSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Protein #5 71 residues (79% resolved)

MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL

MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL
Non polymer #6 A1MBN

InChI=1S/C7H14O3/c1-3-4-7(2,10)5-6(8)9/h10H,3-5H2,1-2H3,(H,8,9)/t7-/m1/s1

CCC[C@](C)(CC(=O)O)O
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