2026-06-13_00000043|hard|30GA

Cryo-EM structure of the PseCascade-TniQ-TnsC-TnsAB holocomplex; Electron microscopy 3.20Å
RNA #1 93 bases

GUGACCUGCCGUAUAGGCAGCUGAAAAUACAGUGGGGCCACUAGGGACAGGAUUGGUGACGUGACCUGCCGUAUAGGCAGCUGAAAAUGUAGC

GUGACCUGCCGUAUAGGCAGCUGAAAAUACAGUGGGGCCACUAGGGACAGGAUUGGUGACGUGACCUGCCGUAUAGGCAGCUGAAAAUGUAGC
DNA #2 145 bases

(DA)(DA)(DT)(DT)(DA)(DT)(DG)(DT)(DC)(DA)(DA)(DG)(DG)(DT)(DA)(DT)(DG)(DG)(DT)(DT)(DG)(DC)(DA)(DT)(DT)(DA)(DT)(DG)(DT)(DC)(DA)(DA)(DA)(DC)(DT)(DA)(DT)(DG)(DG)(DT)(DT)(DG)(DC)(DA)(DG)(DC)(DG)(DA)(DC)(DA)(DG)(DG)(DC)(DC)(DC)(DC)(DG)(DT)(DG)(DG)(DA)(DG)(DC)(DG)(DG)(DA)(DC)(DC)(DT)(DT)(DA)(DA)(DG)(DA)(DA)(DG)(DT)(DT)(DG)(DT)(DG)(DT)(DT)(DC)(DT)(DT)(DC)(DT)(DT)(DT)(DG)(DC)(DC)(DT)(DA)(DG)(DG)(DC)(DC)(DG)(DT)(DC)(DA)(DC)(DC)(DA)(DA)(DT)(DC)(DC)(DT)(DG)(DT)(DC)(DC)(DC)(DT)(DA)(DG)(DT)(DG)(DG)(DC)(DC)(DC)(DC)(DA)(DC)(DT)(DG)(DT)(DG)(DG)(DC)(DT)(DG)(DA)(DG)(DG)(DA)(DT)(DT)(DA)(DC)(DC)

AATTATGTCAAGGTATGGTTGCATTATGTCAAACTATGGTTGCAGCGACAGGCCCCGTGGAGCGGACCTTAAGAAGTTGTGTTCTTCTTTGCCTAGGCCGTCACCAATCCTGTCCCTAGTGGCCCCACTGTGGCTGAGGATTACC
DNA #3 90 bases

(DG)(DG)(DT)(DA)(DA)(DT)(DC)(DC)(DT)(DC)(DA)(DG)(DC)(DC)(DT)(DG)(DT)(DC)(DA)(DC)(DC)(DC)(DC)(DG)(DG)(DT)(DG)(DA)(DT)(DC)(DC)(DC)(DA)(DC)(DA)(DG)(DG)(DA)(DT)(DT)(DG)(DG)(DT)(DG)(DA)(DC)(DG)(DG)(DC)(DC)(DT)(DA)(DG)(DG)(DC)(DA)(DA)(DA)(DG)(DA)(DA)(DG)(DA)(DA)(DC)(DA)(DC)(DA)(DA)(DC)(DT)(DT)(DC)(DT)(DT)(DA)(DA)(DG)(DG)(DT)(DC)(DC)(DG)(DC)(DT)(DC)(DC)(DA)(DC)(DG)

GGTAATCCTCAGCCTGTCACCCCGGTGATCCCACAGGATTGGTGACGGCCTAGGCAAAGAAGAACACAACTTCTTAAGGTCCGCTCCACG
DNA #4 54 bases

(DT)(DT)(DT)(DT)(DT)(DG)(DT)(DC)(DG)(DC)(DT)(DG)(DC)(DA)(DA)(DC)(DC)(DA)(DT)(DA)(DG)(DT)(DT)(DT)(DG)(DA)(DC)(DA)(DT)(DA)(DA)(DT)(DG)(DC)(DA)(DA)(DC)(DC)(DA)(DT)(DA)(DC)(DC)(DT)(DT)(DG)(DA)(DC)(DA)(DT)(DA)(DA)(DT)(DT)

TTTTTGTCGCTGCAACCATAGTTTGACATAATGCAACCATACCTTGACATAATT
Protein #5 350 residues (99% resolved)

MELCNILKYDRSLYPGKAVFFYKTADSDFVPLEADINKIRGPKSGFTEAFTPQFSPKNISPQDLTHNNILTLEECYVPPNVEHIFCRFSLRVQANSLVPSGCSDPEVFSLLKELAETFKECGGYKELAVRYCRNILIGTWLWRNQNTGNTQIEIKTSKGSCYLIDNTRKLAWESKWASDDLKVLEELSNEIESALTDPNVFWSADITAKIEASFCQEIYPSQILNDKVKQGEASKQFVKAKCADGRYAVSFNSVKIGAALQSIDDWWDEDASKRLRVHEFGADKEIGVARRPPDSEQNFYSIFKNTEWYLSALKNCITNKNEKIDPAIYYLFSVLIKGGMFQKKAEAKKA

MELCNILKYDRSLYPGKAVFFYKTADSDFVPLEADINKIRGPKSGFTEAFTPQFSPKNISPQDLTHNNILTLEECYVPPNVEHIFCRFSLRVQANSLVPSGCSDPEVFSLLKELAETFKECGGYKELAVRYCRNILIGTWLWRNQNTGNTQIEIKTSKGSCYLIDNTRKLAWESKWASDDLKVLEELSNEIESALTDPNVFWSADITAKIEASFCQEIYPSQILNDKVKQGEASKQFVKAKCADGRYAVSFNSVKIGAALQSIDDWWDEDASKRLRVHEFGADKEIGVARRPPDSEQNFYSIFKNTEWYLSALKNCITNKNEKIDPAIYYLFSVLIKGGMFQKKAEAKKA
Protein #6 695 residues (98% resolved)

MHLKELLEITDTTERDRSLRRAFSPYTAMIDITGSEAVALIILLNLTYRKNQVDDLLDKKLAKQALKSEDHINKCIKEIAWFHTHNLKYPDIRVSKQNLAVEPPTLHSYVLSSANYPKAYGWSHNSAKVNFAKLFVSYFKWQNQVSWLAQVLATNSDNWKSAFTSLGLSVKAFKSLCVTVKNSLPEEAIPDSVDRYSRQIRMPYHDGYLAVTPVISHVVQSKIQQAAIDKRARFSNVEFTRPAAVSMLAASLGGVINVLNYPPYIRSKYHGLSNSRAFKLNNGQTVFNVEALLKPELIKALEGIIFSNNALALKQRRQQKVKNIKELRNTLLEWFSPVFEWRLDAIENGYDLEQLESASERLEYKILSLPDNELPSLTIPLFRLLNEMLGGVSMTQRYAFHPKLMSPLKAALQWLLVNLTDQKHVLIEEDDEHYRYLHLSGIRVFDAQALSNPYCSGIPSLTAVWGMIHSYQRKLNEALGTNVRFTSFSWFIRNYSAVAGKKLPELSLQGAQQSRLKRPGIIDGKYCDLVFDLIIHIDGYEDDLQAVDSKPDILKAHFPSNFAGGVMHQPELNSNINWCCLYSNENQLFEKLRRLPLSGCWVMPTEHKIQDLDELLLLLNSDSKLSPSMMGYMLLTEPMARVGSLERLHCYAEPAIGVVKYEAATSVRLKGIGNYFNSAFWMLDAQEKFMLMKKV

MHLKELLEITDTTERDRSLRRAFSPYTAMIDITGSEAVALIILLNLTYRKNQVDDLLDKKLAKQALKSEDHINKCIKEIAWFHTHNLKYPDIRVSKQNLAVEPPTLHSYVLSSANYPKAYGWSHNSAKVNFAKLFVSYFKWQNQVSWLAQVLATNSDNWKSAFTSLGLSVKAFKSLCVTVKNSLPEEAIPDSVDRYSRQIRMPYHDGYLAVTPVISHVVQSKIQQAAIDKRARFSNVEFTRPAAVSMLAASLGGVINVLNYPPYIRSKYHGLSNSRAFKLNNGQTVFNVEALLKPELIKALEGIIFSNNALALKQRRQQKVKNIKELRNTLLEWFSPVFEWRLDAIENGYDLEQLESASERLEYKILSLPDNELPSLTIPLFRLLNEMLGGVSMTQRYAFHPKLMSPLKAALQWLLVNLTDQKHVLIEEDDEHYRYLHLSGIRVFDAQALSNPYCSGIPSLTAVWGMIHSYQRKLNEALGTNVRFTSFSWFIRNYSAVAGKKLPELSLQGAQQSRLKRPGIIDGKYCDLVFDLIIHIDGYEDDLQAVDSKPDILKAHFPSNFAGGVMHQPELNSNINWCCLYSNENQLFEKLRRLPLSGCWVMPTEHKIQDLDELLLLLNSDSKLSPSMMGYMLLTEPMARVGSLERLHCYAEPAIGVVKYEAATSVRLKGIGNYFNSAFWMLDAQEKFMLMKKV
Protein #7 237 residues (84% resolved)

MQRYYFTVHFLPKQANLALLTGRCISIMHGFILKHNIEGMGVTFPAWSDSSIGNEIAFVYTDKEILNTLKDQAYFVDMQDCGFFKVSQVLAVPDSCEEVRFIRNQAVAKIFTGESRRRLKRLQKRALARGEDFNPKKIEAPREIDIFHRVAMTSKSSQEDYILHIQKQDVDCQAEPYFSNYGLASNEKFKGTVPDLSPSIDRNSAWSHPQFEKGGGSGGGSGGSAWSHPQFEKSGGG

MQRYYFTVHFLPKQANLALLTGRCISIMHGFILKHNIEGMGVTFPAWSDSSIGNEIAFVYTDKEILNTLKDQAYFVDMQDCGFFKVSQVLAVPDSCEEVRFIRNQAVAKIFTGESRRRLKRLQKRALARGEDFNPKKIEAPREIDIFHRVAMTSKSSQEDYILHIQKQDVDCQAEPYFSNYGLASNEKFKGTVPDLSPSIDRNSAWSHPQFEKGGGSGGGSGGSAWSHPQFEKSGGG
Protein #8 432 residues (94% resolved)

MGHHHHHHHHHHGGSENLYFQSGMAFLFSPKARAFSDESLESYLLRVVSENFFDSYEGLSLAIREELHELDFEAHGAFPVDLKRLNVYHAKHNSHFRMRALGLLETLLDLPRYELQKLALLKSDIKFNSSVALYNNGVDIPLRFIRHHAEEAVDSIPVCSQCLAEEAYIKQSWHIKWVNACTKHQCALLHNCPECYAPINYIENESITHCSCGFELSCASTSPVNTLSIEHLNKLLDKGERNDSNPLFNNMTLTERFAALLWYQERYSQTDNFCLNDAVNYFSKWPAVFNTELDELSKNAEMKLIDLFNKTEFKFIFGDAILACPSTQKQSESHFIYRALLDYLVTLVESNPKTKKPNAADLLVSVLEAATLLGTSVEQVYRLYQNGILQTAFRHKMNQRINPYKGAFFLRHVIEYKTSFGNDKARMYLSAW

MGHHHHHHHHHHGGSENLYFQSGMAFLFSPKARAFSDESLESYLLRVVSENFFDSYEGLSLAIREELHELDFEAHGAFPVDLKRLNVYHAKHNSHFRMRALGLLETLLDLPRYELQKLALLKSDIKFNSSVALYNNGVDIPLRFIRHHAEEAVDSIPVCSQCLAEEAYIKQSWHIKWVNACTKHQCALLHNCPECYAPINYIENESITHCSCGFELSCASTSPVNTLSIEHLNKLLDKGERNDSNPLFNNMTLTERFAALLWYQERYSQTDNFCLNDAVNYFSKWPAVFNTELDELSKNAEMKLIDLFNKTEFKFIFGDAILACPSTQKQSESHFIYRALLDYLVTLVESNPKTKKPNAADLLVSVLEAATLLGTSVEQVYRLYQNGILQTAFRHKMNQRINPYKGAFFLRHVIEYKTSFGNDKARMYLSAW
Protein #9 333 residues (98% resolved)

MNALTEIQIEKLRNFSDCIVMHPQIKTIFNDFDELRLNRKFQSDQQCMLLIGDTGVGKSHTINHYKKRVLATQNYSRNTMPVLVSRISRGKGLDATLVQMLADLELFGSSQIKKRGYKTDLTKKLVESLIKAQVELLIINEFQELIEFKSVQERQQIANGLKFISEEAKVPIVLVGMPWAAKIAEEPQWASRLVRKRKLEYFSLKNDSKYFRQYLMGLAKKMPFDVPPKLESKNTTIALFAACRGENRALKHLLLEALKLALSCNEYLENKHFITAYDKFDFFNDKEKLKSKNPFKQDIKDIEIYEVIKNSSYNPNALDPEDMLTDRVFAIVK

MNALTEIQIEKLRNFSDCIVMHPQIKTIFNDFDELRLNRKFQSDQQCMLLIGDTGVGKSHTINHYKKRVLATQNYSRNTMPVLVSRISRGKGLDATLVQMLADLELFGSSQIKKRGYKTDLTKKLVESLIKAQVELLIINEFQELIEFKSVQERQQIANGLKFISEEAKVPIVLVGMPWAAKIAEEPQWASRLVRKRKLEYFSLKNDSKYFRQYLMGLAKKMPFDVPPKLESKNTTIALFAACRGENRALKHLLLEALKLALSCNEYLENKHFITAYDKFDFFNDKEKLKSKNPFKQDIKDIEIYEVIKNSSYNPNALDPEDMLTDRVFAIVK
Protein #10 1258 residues (63% resolved)

MGSSHHHHHHGSSMKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTNSSSNNNNNNNNNNLGIEENLYFQSNAMYIRNLRKPSPNKNVFKFASTKVSSVVMCESSLEFDACFHHEYNDLIESFGSQPEGFKYEFMGKSLPYTPDALISYTDKTQKYHEYKPYSKIASPLFRAEFAAKRAASLKLGIDLVLVTDRQIRVNPILNNLKLLHRYSGVYGISGIQKELLSFIHKSGVIKLNDISSQVGIPIGETRSFLFGLMHKGLVKADLGCDDLTNNPTLWATPGSGSGKRTADGSEFESPKKKRKVGSGSGGMTDFFNEFDESLVPLKPQTPTQYVKLDDANLIQRDLDTFSDTFKNQALQRYKLISTIDKKLSRGWTQRNLDPILDELFKGGDVVRPNWRTVARWRKKYIESNGDIASLADKNHKMGNRTNRIKGDDKFFDKALERFLDAKRPTIATAYQYYKDLIVIENESIVEGKIPIISYNAFNKRIKAIPPYAVAVARHGKFKADQWFAYCAAHVPPTRILERVEIDHTPLDLILLDDELLIPIGRPYLTLLIDVFSGCVLGFHLSYKSPSYVSAAKAITHAIKPKSLDALNIELQNDWPCFGKFENLVVDNGAEFWSKNLEHACQSAGINIQYNPVRKPWLKPFIERFFGVMNEYFLPELPGKTFSNILEKEEYKPEKDAIMRFSTFVEEFHRWIADVYHQDSNSRETRIPIKRWQQGFDAYPPLTMNEEEETRFSMLMRISDSRTLTRNGFKYQELMYDSTALADYRKHYPQTKETVKKLIKVDPDDISKIYVYLEELESYLEVPCTDPTGYTDGLSIYEHKTIKKINREVIRESKDSLGLAKARMAIHERVKQEQEVFIESKTKAKITAVKKQAQIADVSNTGTSTIKVSEESAAPVQKHISNDNSDDWDDDLEAFE

MGSSHHHHHHGSSMKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTNSSSNNNNNNNNNNLGIEENLYFQSNAMYIRNLRKPSPNKNVFKFASTKVSSVVMCESSLEFDACFHHEYNDLIESFGSQPEGFKYEFMGKSLPYTPDALISYTDKTQKYHEYKPYSKIASPLFRAEFAAKRAASLKLGIDLVLVTDRQIRVNPILNNLKLLHRYSGVYGISGIQKELLSFIHKSGVIKLNDISSQVGIPIGETRSFLFGLMHKGLVKADLGCDDLTNNPTLWATPGSGSGKRTADGSEFESPKKKRKVGSGSGGMTDFFNEFDESLVPLKPQTPTQYVKLDDANLIQRDLDTFSDTFKNQALQRYKLISTIDKKLSRGWTQRNLDPILDELFKGGDVVRPNWRTVARWRKKYIESNGDIASLADKNHKMGNRTNRIKGDDKFFDKALERFLDAKRPTIATAYQYYKDLIVIENESIVEGKIPIISYNAFNKRIKAIPPYAVAVARHGKFKADQWFAYCAAHVPPTRILERVEIDHTPLDLILLDDELLIPIGRPYLTLLIDVFSGCVLGFHLSYKSPSYVSAAKAITHAIKPKSLDALNIELQNDWPCFGKFENLVVDNGAEFWSKNLEHACQSAGINIQYNPVRKPWLKPFIERFFGVMNEYFLPELPGKTFSNILEKEEYKPEKDAIMRFSTFVEEFHRWIADVYHQDSNSRETRIPIKRWQQGFDAYPPLTMNEEEETRFSMLMRISDSRTLTRNGFKYQELMYDSTALADYRKHYPQTKETVKKLIKVDPDDISKIYVYLEELESYLEVPCTDPTGYTDGLSIYEHKTIKKINREVIRESKDSLGLAKARMAIHERVKQEQEVFIESKTKAKITAVKKQAQIADVSNTGTSTIKVSEESAAPVQKHISNDNSDDWDDDLEAFE
Non polymer #11 ATP

InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N
Non polymer #12 MG

InChI=1S/Mg/q+2

[Mg+2]
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Reference