2026-05-23_00000313|hard|9VL2

Structure of CD33 complexed with its mAb-10C8; X-ray diffraction 3.18Å
Protein #1 214 residues (100% resolved)

DPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDLSRNNCSLSIVDARRRDNGSYFFRMERGSTKYSYKSPQLSVHVTDLTHRPKILIPGTLEPGHSKNLTCSVSWACEQGTPPIFSWLSAAPTSLGPRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERTIQLNV

DPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDLSRNNCSLSIVDARRRDNGSYFFRMERGSTKYSYKSPQLSVHVTDLTHRPKILIPGTLEPGHSKNLTCSVSWACEQGTPPIFSWLSAAPTSLGPRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERTIQLNV
Protein #2 213 residues (100% resolved)

TDIQMTQSPSSLSASVGDRVTITCRASQDVYYWVAWYQQKPGKAPKLLISSAGFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYFNFPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG

TDIQMTQSPSSLSASVGDRVTITCRASQDVYYWVAWYQQKPGKAPKLLISSAGFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYFNFPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG
Protein #3 220 residues (97% resolved)

EVQLVESGGGLVQPGGSLRLSCAASGFTINNGWIHWVRQAPGKGLEWVAGIGPYGGSTFYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRFIGSYSHMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKAEPK

EVQLVESGGGLVQPGGSLRLSCAASGFTINNGWIHWVRQAPGKGLEWVAGIGPYGGSTFYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRFIGSYSHMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKAEPK
Non polymer #4 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
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