2026-05-23_00000224|ligand|9SUV

Structure of an inhibitor of Human TGF-beta Type I Receptor; X-ray diffraction 1.50Å
Protein #1 306 residues (94% resolved)

GGTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM

GGTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
Non polymer #2 A1JQO

InChI=1S/C25H29ClFN7O2S/c1-33-8-10-34(11-9-33)7-5-24(36)30-23-15-18(4-6-28-23)29-22-16-21(31-32-25(22)37-13-12-35)19-14-17(26)2-3-20(19)27/h2-4,6,14-16,35H,5,7-13H2,1H3,(H2,28,29,30,31,36)

CN1CCN(CC1)CCC(=O)Nc2cc(ccn2)Nc3cc(nnc3SCCO)c4cc(ccc4F)Cl
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Reference