2026-05-23_00000153|hard|9QTY

Cryo-EM structure of the binary MEGF8-MOSMO complex with nanobody 270; Electron microscopy 2.98Å

Protein #1 211 residues (77% resolved)

Raw Sequence ...

MDKLTIISGCLFLAADIFAIASIANPDWINTGESAGALTVGLVRQCQTIHGRDRTCIPPRLPPEWVTTLFFIIMGIISLTVTCGLLVASHWRREATKYARWIAFTGMILFCMAALIFPIGFYINEVGGQPYKLPNNTVVGSSYVLFVLSIFFTIVGLLFAGKVCLPGGTLEVLFQGPGGSGSAWSHPQFEKGGGSGGGSGGSAWSHPQFEK

Canonical Sequence ...

Protein #2 129 residues (92% resolved)

Raw Sequence ...

QVQLVESGGGLVQAGGSLRLSCAASGSIFSYDDMGWYRQAPGKQRELVATFTNVGSTNYVDSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCHAYTVRRFQGMEYWGKGTQVTVSSHHHHHHEPEA

Canonical Sequence ...

QVQLVESGGGLVQAGGSLRLSCAASGSIFSYDDMGWYRQAPGKQRELVATFTNVGSTNYVDSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCHAYTVRRFQGMEYWGKGTQVTVSSHHHHHHEPEA

Protein #3 344 residues (59% resolved)

Raw Sequence ...

KCQCNGHADTCNEQDGTGCPCQNNTETGTCQGSSPSDRRDCYKYQCAKCRESFHGSPLGGQQCYRLISVEQECCLDPTSQTNCFHEPKRRALGPGRTVLFGVQPKFTNVDIRLTLDVTFGAVDLYVSTSYDTFVVRVAPDTGVHTVHIQPPPAPPPPPPPADGGPRGAGDPGGAGASSGPGAPAEPRVREVWPRGLITYVTVTEPSAVLVVRGVRDRLVITYPHEHHALKSSRFYLLLLGVGDPSGPGANGSADSQGLLFFRQDQAHIDLFVFFSVFFSCFFLFLSLCVLLWKAKQALDQRQEQRRHLQEMTKMASRPFAKVTVCFPPDPTAPAGTETSQVAPA

Canonical Sequence ...

Non polymer #4 A1JAX

InChI=1S/C28H44O3/c1-17-8-13-28(30-16-17)18(2)25-24(31-28)15-23-21-7-6-19-14-20(29-5)9-11-26(19,3)22(21)10-12-27(23,25)4/h6,17-18,20-25H,7-16H2,1-5H3/t17-,18+,20+,21-,22+,23+,24+,25+,26+,27+,28-/m1/s1

InChI=1S/C28H44O3/c1-17-8-13-28(30-16-17)18(2)25-24(31-28)15-23-21-7-6-19-14-20(29-5)9-11-26(19,3)22(21)10-12-27(23,25)4/h6,17-18,20-25H,7-16H2,1-5H3/t17-,18+,20+,21-,22+,23+,24+,25+,26+,27+,28-/m1/s1

SMILES: C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5(CC[C@@H](C6)OC)C)C)C)OC1

C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5(CC[C@@H](C6)OC)C)C)C)OC1

Non polymer #5 PLM

InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)

SMILES: CCCCCCCCCCCCCCCC(=O)O

CCCCCCCCCCCCCCCC(=O)O

Biounit #1 hetero-1-1-1-mer

Reference