2026-05-23_00000120|hard|9ON3

Cryo-EM structure of the salivary protein complex Saglin-SGS4 from Anopheles gambiae; Electron microscopy 3.40Å
Protein #1 3398 residues (80% resolved)

MDAPKQFYSLQLPGKSLTKAPPGNTVEVKRAPSAEQIIFVRNNRALLIYERMGGSWSEVHKRNNFFAVSNDDASYPWAVYDDGLLAVRKVKGFVLYRWNKKELNELLVAAKYHDEYGYALSNNTILFGNIYPSAEYIGVISRLHSVVEFSSAKPSDPRKRVRPLKKQLDLEAAWMQPSSTISLVERYDNNAQLSIALRTAAELKLFRFDNQYQLKELATVKDFLPLDDEYDRIMFAKFDDANINDLLHFTTKGLTMYRFFEESGVFEKVYYSTAFSKLRGWNRRTIESIATVNIDGDKWDELIASGPRGLCLYRPVFGNDGFELVNIFDETIEDGEMRYGIPKLTTKLADSDGFNVLLFTGANLVSVQTKPYIPRIYDVPSAAQTVVKANAVAPLLVPQKKYIVWLHDQLDLNSMLQPLNPHAGTVELSIPLIELPNAFGVSVRKYVQYKNIPFESFFGRGWSLPLDYISVERKNSAFLQDHDYAVLKNNNRIILKRYPHLDSVDCWSFEIDGFKQATIKYYPSKERWEMTMEDRTFVYGAWENLSKRREEDVCASWPLCGEKSAKKRKLPSRWYLVHEESKYGAYANYYYDPLVEGKGDRLARIELSSGSSVSFKYSEQNKLVNFKVNTTCYEQNVSFEYEGNWLKQINQEDRPLFKFDYKDDRMWKIVYPNRLESMLEYSDVQIDRTRFEEAVPVDLNPTIYYGPDYTVILDKEFEDDRVAITIRNLLGGTDGPKAMKEKLHFGQPGIKSHTIHALEDMLVVVLIYGSQKEVTVLQFTGNDWVEKEYISDFPLDAVISVGKKFVVLCDLKTLRVLTINHKGNLNDTEVQKSLPPKFLIHTFGNGFLMCSASSIDVWTMGIKNEWQKGSTQAPTNIFTDIDKLLNAFVLDAEFSTALRKGFLADAVTVYQNAIVIRVPVLDGQKLNLKVFFLIMNYDRGATQVSKQTVQIPIANFDTYEYDMPTKDGDVFKLHYKVQNNKYVLKLKSMKGPLNNSLTEQKQKSYKQIDASGEAVEKKAQYKKEVDEKFAEEVDNISQTVVSKAQFAMDLSQFGVLTNQHGVVTGNVQLSFDGQTWQQQPIDPATMRMEKVDQPLGAGFKLAKYSYQDTFKVYEMPRHAVVYDTQTNNPQEIQVVAPRYIQSQPAGKQLSMFFFHTKETIQQPANVTMVRASNTISLVTVRHVNETSKFVVFRPVDSFLLKMTSLFTKQRVRLDQDELRTSSYNYHPRDVHLSSEGAMFYRVKVAPGDNEKRFGWYEQATNSSTGATTKKSFAADGTDVTVREKPKQESNRDADVKDLERTIWDRSKQLKIIDLGALKLADEVASYYGFEAYELNRYGVDKEWSFNLADVQFERDNHYLKLPASSTLKATFTPTEPKNLWIVSFWVRIGNGEMVPKVDDMLNVLMVELVNLNNQKRVQLTGAKVHHIMSNWCYAEMTIDTTHTADGSKLSFNITIKPSESHTSIDVDHVRFSPLNLNFRANVYTPDTAEVRATLCNNGLLKQNLYSPTGKRVALLSEDGQVVDFAMHSKTAFVASVNARQCLIEMKPNYGTFETFEPSYWKQGSTEWSIRYGEVEYNPGSVAQRGELSRTFDRPFESVALRFVYNTSVDDSKLSFSWNGQEFNLFCSTGSSNSCNRPPKAGEVLIFITELRVSVWLEGHLLSETLIKPDSRVQALKEFRLLPTGSIKIAEFLVMYDARVKVTYHNRMGRPVQVVVYDDPRTVRVREIIYDEIDRPIMQTKWTKLTSHLKEYFAFYENFITQVHGTSHVMSGMVAKAHPSCEGFPYSRTIYANDPTENKQYQGLPGKEYTVLGKYKRRYAMRPEIKVLANIFPVAEGYRQSIVERPGGAIRATVEDKRGNKVAKYWQVGNYEHRLTTYTYSETYGHLIEVLPPQFHALAKTTSRTRPFLTGGNTQEEIKLRNLWRVSYEYDYGNLIDKRTPDGGTYEYIYSESGILRFSIHYNAPERVNMDRVVHFTYSSHGKVMREALVNLTRESCYQIVKTNEVPESTDLIESFYGEVESNPDVRYRSQQSTRKIGKNQMMESLIFDENEQVIKKVFFVPTINRTYSIDYEYENGKLHSLRYPMDSAASSFTLIYDYNKNGEVKSIKESTKRVPMFEFSYNADGMVETMNVRTDPTHTFQRNFTYNEPGFLIKLADNYLTESVSYLETDSYGQDSYTPIYEGLISKTLFTAHWQKATSPLRNGIYTEYLMSDNMNRAQASLCLEVLKRTGYIDENNLVNRTLYGDMNDDLPFVCGKRLALNHLSKVLSTRSFPYQYGHRYDYDDHDQLIKAKYFHGLEELKLAPLTHHTFHKEIKGIDEAKSKKIWDALREKSFLTTDCTNPSLCHGREGTKSIFNDFIHQHRYSHHLKLMLSKAISARKGLDVKTFEEKCTRWIEGSNMILKACTNLKEEMMKQKLFGESADAPVASLNEAFKKALQRYKSNVPDIVGVLNHHFMTALGRSAGDVQSYEIDANGNHRMFYTGFSRYRLEYQEGTNKITKLYRQQFDRAQGGREEFTMAHDGDGAVIQAQHKGIKHMAYDKLLQRVSEIEMTDGRKILYQYDVRAERTFKQVRGKDGKVMSEKYYIRDANGLVLMDMDMSYLASDQPPDVRVTSYIYKDQQLIVFVRNDKLYGVITDHEGSVRLVVREGEVVAAYDYLPYGQIFRRFGTDLDGQISYLYTGQEWEPETGLYNYRARLYDPDIGRFYQMDPKEQYPSPYVYAGNSPVSLIDPDGEFAFTLAVLILALVGAYLGAASANNCWNPLKWDWRSSSTWIGLLTGAVTGASIPFNMASSVAFFVGMGLSLSTSIAIMVGTGITFAYFMMAASSGTWDPTKFDYSSPGTWNALMNGVATSSWILMNPSSLISSFVSITSVAAKALFFVAKLTMSLGFTYLFAALGQGGEFDMTKWDYSDPALYMSFVDGFTTATVGVLFLRNLPRQISKWSGKVKRTVDIFVANMITFRAQLALGRDWSRLIMHTKNFLYVGVRNLQTLQKGFLTVGFYSLIVSLRMSLISESAIPEFTAAEASINVLFSTEQFSDFIVKPLSKASPKLRLPKPPNLARMLRFRIRSDAIRIGSNESIVVPNHMERSSASSLHNMFNNWIKLPFEWLFSTSMRENENEFDKRVSMISAPTRNMAKSAFSLRNCYKIYSEEHLDGMISCFGHSSTVTIIPKFESNPRIENADHYKYCMPLTYDGHPSASCEGEWSSLVYTAKETARVFDFVDGWILLAQVAPIAWKEIKLGFKYIFSRPKRDQQVSHTDMVEYEKKMLYCRLDEMKTQINTHQQLSWAQWTYEDLAEDVEVYLNKGQGSMNLLDERINALEAEIKEDFILQRLQSVLREHCATDSSVHVRRNANSKIDFLYAGQTNSHKVQNVVSAFDLLGDNVKFNAILQSKSN

MDAPKQFYSLQLPGKSLTKAPPGNTVEVKRAPSAEQIIFVRNNRALLIYERMGGSWSEVHKRNNFFAVSNDDASYPWAVYDDGLLAVRKVKGFVLYRWNKKELNELLVAAKYHDEYGYALSNNTILFGNIYPSAEYIGVISRLHSVVEFSSAKPSDPRKRVRPLKKQLDLEAAWMQPSSTISLVERYDNNAQLSIALRTAAELKLFRFDNQYQLKELATVKDFLPLDDEYDRIMFAKFDDANINDLLHFTTKGLTMYRFFEESGVFEKVYYSTAFSKLRGWNRRTIESIATVNIDGDKWDELIASGPRGLCLYRPVFGNDGFELVNIFDETIEDGEMRYGIPKLTTKLADSDGFNVLLFTGANLVSVQTKPYIPRIYDVPSAAQTVVKANAVAPLLVPQKKYIVWLHDQLDLNSMLQPLNPHAGTVELSIPLIELPNAFGVSVRKYVQYKNIPFESFFGRGWSLPLDYISVERKNSAFLQDHDYAVLKNNNRIILKRYPHLDSVDCWSFEIDGFKQATIKYYPSKERWEMTMEDRTFVYGAWENLSKRREEDVCASWPLCGEKSAKKRKLPSRWYLVHEESKYGAYANYYYDPLVEGKGDRLARIELSSGSSVSFKYSEQNKLVNFKVNTTCYEQNVSFEYEGNWLKQINQEDRPLFKFDYKDDRMWKIVYPNRLESMLEYSDVQIDRTRFEEAVPVDLNPTIYYGPDYTVILDKEFEDDRVAITIRNLLGGTDGPKAMKEKLHFGQPGIKSHTIHALEDMLVVVLIYGSQKEVTVLQFTGNDWVEKEYISDFPLDAVISVGKKFVVLCDLKTLRVLTINHKGNLNDTEVQKSLPPKFLIHTFGNGFLMCSASSIDVWTMGIKNEWQKGSTQAPTNIFTDIDKLLNAFVLDAEFSTALRKGFLADAVTVYQNAIVIRVPVLDGQKLNLKVFFLIMNYDRGATQVSKQTVQIPIANFDTYEYDMPTKDGDVFKLHYKVQNNKYVLKLKSMKGPLNNSLTEQKQKSYKQIDASGEAVEKKAQYKKEVDEKFAEEVDNISQTVVSKAQFAMDLSQFGVLTNQHGVVTGNVQLSFDGQTWQQQPIDPATMRMEKVDQPLGAGFKLAKYSYQDTFKVYEMPRHAVVYDTQTNNPQEIQVVAPRYIQSQPAGKQLSMFFFHTKETIQQPANVTMVRASNTISLVTVRHVNETSKFVVFRPVDSFLLKMTSLFTKQRVRLDQDELRTSSYNYHPRDVHLSSEGAMFYRVKVAPGDNEKRFGWYEQATNSSTGATTKKSFAADGTDVTVREKPKQESNRDADVKDLERTIWDRSKQLKIIDLGALKLADEVASYYGFEAYELNRYGVDKEWSFNLADVQFERDNHYLKLPASSTLKATFTPTEPKNLWIVSFWVRIGNGEMVPKVDDMLNVLMVELVNLNNQKRVQLTGAKVHHIMSNWCYAEMTIDTTHTADGSKLSFNITIKPSESHTSIDVDHVRFSPLNLNFRANVYTPDTAEVRATLCNNGLLKQNLYSPTGKRVALLSEDGQVVDFAMHSKTAFVASVNARQCLIEMKPNYGTFETFEPSYWKQGSTEWSIRYGEVEYNPGSVAQRGELSRTFDRPFESVALRFVYNTSVDDSKLSFSWNGQEFNLFCSTGSSNSCNRPPKAGEVLIFITELRVSVWLEGHLLSETLIKPDSRVQALKEFRLLPTGSIKIAEFLVMYDARVKVTYHNRMGRPVQVVVYDDPRTVRVREIIYDEIDRPIMQTKWTKLTSHLKEYFAFYENFITQVHGTSHVMSGMVAKAHPSCEGFPYSRTIYANDPTENKQYQGLPGKEYTVLGKYKRRYAMRPEIKVLANIFPVAEGYRQSIVERPGGAIRATVEDKRGNKVAKYWQVGNYEHRLTTYTYSETYGHLIEVLPPQFHALAKTTSRTRPFLTGGNTQEEIKLRNLWRVSYEYDYGNLIDKRTPDGGTYEYIYSESGILRFSIHYNAPERVNMDRVVHFTYSSHGKVMREALVNLTRESCYQIVKTNEVPESTDLIESFYGEVESNPDVRYRSQQSTRKIGKNQMMESLIFDENEQVIKKVFFVPTINRTYSIDYEYENGKLHSLRYPMDSAASSFTLIYDYNKNGEVKSIKESTKRVPMFEFSYNADGMVETMNVRTDPTHTFQRNFTYNEPGFLIKLADNYLTESVSYLETDSYGQDSYTPIYEGLISKTLFTAHWQKATSPLRNGIYTEYLMSDNMNRAQASLCLEVLKRTGYIDENNLVNRTLYGDMNDDLPFVCGKRLALNHLSKVLSTRSFPYQYGHRYDYDDHDQLIKAKYFHGLEELKLAPLTHHTFHKEIKGIDEAKSKKIWDALREKSFLTTDCTNPSLCHGREGTKSIFNDFIHQHRYSHHLKLMLSKAISARKGLDVKTFEEKCTRWIEGSNMILKACTNLKEEMMKQKLFGESADAPVASLNEAFKKALQRYKSNVPDIVGVLNHHFMTALGRSAGDVQSYEIDANGNHRMFYTGFSRYRLEYQEGTNKITKLYRQQFDRAQGGREEFTMAHDGDGAVIQAQHKGIKHMAYDKLLQRVSEIEMTDGRKILYQYDVRAERTFKQVRGKDGKVMSEKYYIRDANGLVLMDMDMSYLASDQPPDVRVTSYIYKDQQLIVFVRNDKLYGVITDHEGSVRLVVREGEVVAAYDYLPYGQIFRRFGTDLDGQISYLYTGQEWEPETGLYNYRARLYDPDIGRFYQMDPKEQYPSPYVYAGNSPVSLIDPDGEFAFTLAVLILALVGAYLGAASANNCWNPLKWDWRSSSTWIGLLTGAVTGASIPFNMASSVAFFVGMGLSLSTSIAIMVGTGITFAYFMMAASSGTWDPTKFDYSSPGTWNALMNGVATSSWILMNPSSLISSFVSITSVAAKALFFVAKLTMSLGFTYLFAALGQGGEFDMTKWDYSDPALYMSFVDGFTTATVGVLFLRNLPRQISKWSGKVKRTVDIFVANMITFRAQLALGRDWSRLIMHTKNFLYVGVRNLQTLQKGFLTVGFYSLIVSLRMSLISESAIPEFTAAEASINVLFSTEQFSDFIVKPLSKASPKLRLPKPPNLARMLRFRIRSDAIRIGSNESIVVPNHMERSSASSLHNMFNNWIKLPFEWLFSTSMRENENEFDKRVSMISAPTRNMAKSAFSLRNCYKIYSEEHLDGMISCFGHSSTVTIIPKFESNPRIENADHYKYCMPLTYDGHPSASCEGEWSSLVYTAKETARVFDFVDGWILLAQVAPIAWKEIKLGFKYIFSRPKRDQQVSHTDMVEYEKKMLYCRLDEMKTQINTHQQLSWAQWTYEDLAEDVEVYLNKGQGSMNLLDERINALEAEIKEDFILQRLQSVLREHCATDSSVHVRRNANSKIDFLYAGQTNSHKVQNVVSAFDLLGDNVKFNAILQSKSN
Protein #2 392 residues (99% resolved)

GQEATEDPFADETDQCQISVSAETMKSLHGGSMQPDGTCDNLWESFLSQFHQVRENLTACQERAAAGPAPDPSSQFCQQLLDDAQRQMEQEHRQYAATLEEQLHAAQQETQQEQEMKKALQKQLDALTDSRNALYIDLLLANIAIGETKQALSYYNLMPASMPIDKLHEQIVRFVYRVTIYQDQRLLNLMRFVRDIPSVEERRSLYQLAQREVQKRPSQRDGYVAAVYALSVREDLPVYQANRQLYDDLVRQSETRLKEQVANGNFKQAAELAARQPQHFRQLQTSLATIELKHWRKFDRFVPYANALPQPAQRLEVLRVLLSQIGDREKKTSHKYLVKAARQFDICEQFIGRGKVDQAVKKQLEELRGKFATFAKGKNYQHYLSESRKSSG

GQEATEDPFADETDQCQISVSAETMKSLHGGSMQPDGTCDNLWESFLSQFHQVRENLTACQERAAAGPAPDPSSQFCQQLLDDAQRQMEQEHRQYAATLEEQLHAAQQETQQEQEMKKALQKQLDALTDSRNALYIDLLLANIAIGETKQALSYYNLMPASMPIDKLHEQIVRFVYRVTIYQDQRLLNLMRFVRDIPSVEERRSLYQLAQREVQKRPSQRDGYVAAVYALSVREDLPVYQANRQLYDDLVRQSETRLKEQVANGNFKQAAELAARQPQHFRQLQTSLATIELKHWRKFDRFVPYANALPQPAQRLEVLRVLLSQIGDREKKTSHKYLVKAARQFDICEQFIGRGKVDQAVKKQLEELRGKFATFAKGKNYQHYLSESRKSSG
Non polymer #3 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

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Reference