2026-05-16_00000074|ligand|7I95

Crystal Structure of 25 bound to the PH domain of Btk; X-ray diffraction 1.99Å
Protein #1 169 residues (99% resolved)

AAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPAFWIDGQYLCCSQTAKNAMGCQILEN

AAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPAFWIDGQYLCCSQTAKNAMGCQILEN
Non polymer #2 A1B6V

InChI=1S/C16H15ClO4/c1-20-13-4-2-3-10(15(13)17)9-5-6-11-12(16(18)19)8-21-14(11)7-9/h2-4,8-9H,5-7H2,1H3,(H,18,19)/t9-/m0/s1

COc1cccc(c1Cl)[C@H]2CCc3c(coc3C2)C(=O)O
Non polymer #3 MG

InChI=1S/Mg/q+2

[Mg+2]
Non polymer #4 ZN

InChI=1S/Zn/q+2

[Zn+2]
Download coordinates
Download coordinates
Reference