2026-05-09_00000187|hard|9VMG

Cryo-EM structure of the spermine-bound sea lamprey TAAR348-Gs complex; Electron microscopy 2.82Å
Protein #1 348 residues (82% resolved)

MSSHANTTSPACGLTFYDFNCSRASVTSSSERAQVMSLLLSISAITIAGNLLTITSILYFRQLQTRTNVLTLSLAVADLLVGLLIMPFSVMRSVHNCWFYGRVFCRVHTWLDYTFCTSSIVHLSCISFDRYVAISDPLRYEQRVTRRACVRMLVCCWLCLLVYGLAFMMEWNLVGLEEEVAHICPDDCPVLLNLPFAMANTIFACIVPMMLMTLAYGRIYQLARQQARKITSAAVGSNADSARSSLRREHSATITMGIIVGVFISLWIPYFVVSVTEPIFGYHASSVTWEVINWFTYINSTANPILFAAFNRPFRNAFYLILSGRMFASSCRGVDLFDVLRALAKARG

MSSHANTTSPACGLTFYDFNCSRASVTSSSERAQVMSLLLSISAITIAGNLLTITSILYFRQLQTRTNVLTLSLAVADLLVGLLIMPFSVMRSVHNCWFYGRVFCRVHTWLDYTFCTSSIVHLSCISFDRYVAISDPLRYEQRVTRRACVRMLVCCWLCLLVYGLAFMMEWNLVGLEEEVAHICPDDCPVLLNLPFAMANTIFACIVPMMLMTLAYGRIYQLARQQARKITSAAVGSNADSARSSLRREHSATITMGIIVGVFISLWIPYFVVSVTEPIFGYHASSVTWEVINWFTYINSTANPILFAAFNRPFRNAFYLILSGRMFASSCRGVDLFDVLRALAKARG
Protein #2 247 residues (93% resolved)

MGSTVSAEDKAAAERSKMIDKNLREDGEKAAAATHRLLLLGADNSGKSTIVKQMRIYHGGSGGSGGTSGIFETKFQVDKVNFHMFDVGAQRDERRKWIQCFNDVTAIIFVVDSSDYNRLQEALNDFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCSVDTENARRIFNDCRDIIQRMHLRQYELL

MGSTVSAEDKAAAERSKMIDKNLREDGEKAAAATHRLLLLGADNSGKSTIVKQMRIYHGGSGGSGGTSGIFETKFQVDKVNFHMFDVGAQRDERRKWIQCFNDVTAIIFVVDSSDYNRLQEALNDFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCSVDTENARRIFNDCRDIIQRMHLRQYELL
Protein #3 340 residues (99% resolved)

MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Protein #4 71 residues (80% resolved)

MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL

MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL
Protein #5 139 residues (91% resolved)

MQVQLQESGGGLVQPGGSLRLSCAASGFTFSNYKMNWVRQAPGKGLEWVSDISQSGASISYTGSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCARCPAPFTRDCFDVTSTTYAYRGQGTQVTVSSHHHHHHEPEA

MQVQLQESGGGLVQPGGSLRLSCAASGFTFSNYKMNWVRQAPGKGLEWVSDISQSGASISYTGSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCARCPAPFTRDCFDVTSTTYAYRGQGTQVTVSSHHHHHHEPEA
Protein #6 259 residues (90% resolved)

DVQLVESGGGLVQPGGSRKLSCSASGFAFSSFGMHWVRQAPEKGLEWVAYISSGSGTIYYADTVKGRFTISRDDPKNTLFLQMTSLRSEDTAMYYCVRSIYYYGSSPFDFWGQGTTLTVSSGGGGSGGGGSGGGGSDIVMTQATSSVPVTPGESVSISCRSSKSLLHSNGNTYLYWFLQRPGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLTISRLEAEDVGVYYCMQHLEYPLTFGAGTKLELKAAAHHHHHHHH

DVQLVESGGGLVQPGGSRKLSCSASGFAFSSFGMHWVRQAPEKGLEWVAYISSGSGTIYYADTVKGRFTISRDDPKNTLFLQMTSLRSEDTAMYYCVRSIYYYGSSPFDFWGQGTTLTVSSGGGGSGGGGSGGGGSDIVMTQATSSVPVTPGESVSISCRSSKSLLHSNGNTYLYWFLQRPGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLTISRLEAEDVGVYYCMQHLEYPLTFGAGTKLELKAAAHHHHHHHH
Non polymer #7 SPM

InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2

C(CCNCCCN)CNCCCN
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