2026-05-09_00000079|hard|9OH4

Cryo-EM structure of cGAS tetramer in complex with BuDNA (bubble DNA); Electron microscopy 3.48Å
Protein #1 357 residues (100% resolved)

KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTGSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPLSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFD

KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTGSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPLSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFD
DNA #2 41 bases

(DC)(DA)(DC)(DA)(DG)(DA)(DG)(DA)(DA)(DG)(DA)(DA)(DC)(DA)(DT)(DT)(DT)(DG)(DA)(DC)(DC)(DC)(DG)(DG)(DG)(DT)(DA)(DA)(DA)(DG)(DC)(DT)(DA)(DA)(DT)(DA)(DA)(DC)(DA)(DA)(DG)

CACAGAGAAGAACATTTGACCCGGGTAAAGCTAATAACAAG
DNA #3 41 bases

(DC)(DT)(DT)(DG)(DT)(DT)(DA)(DT)(DT)(DA)(DG)(DC)(DT)(DT)(DT)(DA)(DC)(DC)(DC)(DG)(DG)(DG)(DT)(DC)(DA)(DA)(DA)(DT)(DG)(DT)(DT)(DC)(DT)(DT)(DC)(DT)(DC)(DT)(DG)(DT)(DG)

CTTGTTATTAGCTTTACCCGGGTCAAATGTTCTTCTCTGTG
Non polymer #4 ZN

InChI=1S/Zn/q+2

[Zn+2]
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Reference