2026-05-02_00000237
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ligand
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9VLM
The X-RAY co-crystal structure of human FGFR2 and covalent inhibitor 10a;
X-ray diffraction 2.26Å
Protein #1
303 residues (92% resolved)
Raw Sequence ...
GPEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT
Canonical Sequence ...
GPEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT
Non polymer #2
A1ESP
InChI=1S/C27H33N7O3S/c1-5-26(35)30-21-9-10-22-23(17-34(4)25(22)16-21)24-11-12-28-27(32-24)31-20-8-6-7-19(15-20)18-38(36,37)29-13-14-33(2)3/h6-12,15-17,29H,5,13-14,18H2,1-4H3,(H,30,35)(H,28,31,32)
InChI=1S/C27H33N7O3S/c1-5-26(35)30-21-9-10-22-23(17-34(4)25(22)16-21)24-11-12-28-27(32-24)31-20-8-6-7-19(15-20)18-38(36,37)29-13-14-33(2)3/h6-12,15-17,29H,5,13-14,18H2,1-4H3,(H,30,35)(H,28,31,32)
SMILES: CCC(=O)Nc1ccc2c(c1)n(cc2c3ccnc(n3)Nc4cccc(c4)CS(=O)(=O)NCCN(C)C)C
CCC(=O)Nc1ccc2c(c1)n(cc2c3ccnc(n3)Nc4cccc(c4)CS(=O)(=O)NCCN(C)C)C
Biounit #1
monomer
Download coordinates
Biounit #2
monomer
Download coordinates
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Model
Reference
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