2026-05-02_00000236|ligand|9VLJ

Crystal structure of FGFR1 in complex with covalent inhibitor 10a; X-ray diffraction 1.81Å
Protein #1 310 residues (100% resolved)

GPAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE

GPAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE
Non polymer #2 A1ESP

InChI=1S/C27H33N7O3S/c1-5-26(35)30-21-9-10-22-23(17-34(4)25(22)16-21)24-11-12-28-27(32-24)31-20-8-6-7-19(15-20)18-38(36,37)29-13-14-33(2)3/h6-12,15-17,29H,5,13-14,18H2,1-4H3,(H,30,35)(H,28,31,32)

CCC(=O)Nc1ccc2c(c1)n(cc2c3ccnc(n3)Nc4cccc(c4)CS(=O)(=O)NCCN(C)C)C
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Reference