2026-05-02_00000214|hard|9UVZ

Cryo-EM structure of Lysophosphatidic acid receptor 2 (LPA2)-ARK1 with Ki16425; Electron microscopy 2.99Å
Protein #1 759 residues (90% resolved)

MKTIIALSYIFCLVFADYKDDDDAENLYFQGMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMLELRRLLREQGEKLLKLAEESEKKIKEAIEKGEDVVKVATEETHKLIKAIWESSFEVARLLGVPEEVLEKFRKELEKLLEESKKRIEEAIKKGEDVLKVVEEEAKKLREHSEKFLETARSLGVDPRPLERLARIVRVVEESLVRIVKAIKEGEDVEKVLLSESTLIKSSIILSSGLDPREAYEELLATYEETRDSELVKEFVELVRELLRLRGEPEELVRQLDKLIEAIDRMEKAVAEGEDTLPLFLELAREILKALSDVARILAEREGLDVELIDEIVDTASRLLEEVIKKAKEGEDLDEEEEKVKKELEELKKRTEERARALGQDVELVRTIVDSLSTLLSEIVEGIKRVKEGEDPLEVLARVVLTATLQILELVRTAERRRRERTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTLLEVLFQ

MKTIIALSYIFCLVFADYKDDDDAENLYFQGMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMLELRRLLREQGEKLLKLAEESEKKIKEAIEKGEDVVKVATEETHKLIKAIWESSFEVARLLGVPEEVLEKFRKELEKLLEESKKRIEEAIKKGEDVLKVVEEEAKKLREHSEKFLETARSLGVDPRPLERLARIVRVVEESLVRIVKAIKEGEDVEKVLLSESTLIKSSIILSSGLDPREAYEELLATYEETRDSELVKEFVELVRELLRLRGEPEELVRQLDKLIEAIDRMEKAVAEGEDTLPLFLELAREILKALSDVARILAEREGLDVELIDEIVDTASRLLEEVIKKAKEGEDLDEEEEKVKKELEELKKRTEERARALGQDVELVRTIVDSLSTLLSEIVEGIKRVKEGEDPLEVLARVVLTATLQILELVRTAERRRRERTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTLLEVLFQ
Non polymer #2 A1L9P

InChI=1S/C23H23ClN2O5S/c1-14-21(25-23(29)30-15(2)18-5-3-4-6-19(18)24)22(31-26-14)17-9-7-16(8-10-17)13-32-12-11-20(27)28/h3-10,15H,11-13H2,1-2H3,(H,25,29)(H,27,28)/t15-/m1/s1

Cc1c(c(on1)c2ccc(cc2)CSCCC(=O)O)NC(=O)O[C@H](C)c3ccccc3Cl
Non polymer #3 NA

InChI=1S/Na/q+1

[Na+]
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Reference