2026-04-25_00000256|medium|9VY0

Cryo-EM Structure of Peste Des Petits Ruminants Virus Polymerase in complex with ERDRP-0519; Electron microscopy 2.71Å
Protein #1 2183 residues (54% resolved)

MDSLSVNQVLYPEVHLDSPIVTNKLVAILEYSGIDHNYVLEDQTLVKNIRYRLGCGFSNQMIINNRGVGETVNSKLKSYPHNRHIIYPDCNKELFCIKDSCISKKLSELFKKGNSLYSKISHQVLDCLKRVNGKLGLGTDLTYGLKEGILDLGLHMHSSQWFETFLFWFTIKTEMRSMIKEQSHICHKRRYNPIFVSGDAFEVLVSRDLVVIIDKNTQYVFYLTFELVLMYCDVIEGRLMTETAMAIDQRYSELLSRVRYLWDLIDGFFPTLGNTTYQVVALLEPLSLAYLQLQDVTLELRGAFLDHCFKELYEILEHCGIDTEGTYNSITEGLDYVFITHDIHLTGEIFSFFRSFGHPRLEAVTAAENVRKHMNQPKVISYETMMKGHAVFCGIIINGFRDRHGGSWPPVALPEHASAAIRNAQASGEGLTHDLCIDNWKSFVGFKFGCFMPLSLDSDLTMYLKDKALAALKNEWDSVYPKEYLRYNPPRGTESRRLVEVFLNDSSFDPYNMIMYVVNGSYLKDPEFNLSYSLKEKEIKETGRLFAKMTYKMRACQVIAENLISNGVGKYFRDNGMAKDEHDLTKALHTLAVSGVPKNNKDNHRGGPPRRTTNREVRSSQDTKTQNRDKVQGGPVYNYLRCQPISPDQGESYETVSAFITADLKKYCLNWRYETISIFAQRLNEIYGLPSFFQWLHRILEKSVLYVSDPHCPPDLDNHIPLDSVPNAQIFIKYPMGGIEGYCQKLWTISTIPYLYLAAYESGVRIASLVQGDNQTIAVTKRVPSSWPYSLKKREASKAAQNYFVVLRQRLHDVGHHLKANETIVSSHFFVYSKGIYYDGLLVSQSLKSIARCVFWSETIVDETRAACSNIATTVAKSIERGYDRYLAYSLNILKIFQQILISLNFTINTTMTQDVVAPIIENGDLLIRMALLPAPIGGLNYLNMSRLFVRNIGDPVTSSIADLKRMIDAGLMPEETLHQVMTQTPGESSYLDWASDPYSANLPCVQSITRLLKNITARYILISSPNPMLKGLFHEGSRDEDEELASFLMDRHIIVPRAAHEILDHSITGAREAIAGMLDTTKGLIRTSMKRGGLTPRVLARLSNYDYEQFRSGITLLTKKGQCYLIDKDSCSVQLAIALRSHMWARLARGRPIYGLEVPDILESMNGYLIKRHESCAICETGSSHYGWFFVPAGCQLDDVSRETSALRVPYVGSTTEERTDMKLAFVRSPSRSLKSAVRIATVYSWAYGDDEKSWGEAWMLARQRANITLDELRMITPVSTSTNLAHRLRDRSTQVKYSGTSLVRVARYTTISNDNLSFVISEKKVDTNFIYQQGMLLGLGILENLFRLEATTGVSNTVLHLHVETECCVVPMVDHPRIPSLRNIKVTDELCTNPLIYDRSPIIEHDATRLYSQSHRRHLVEFVTWSTSQLYHILAKSTAMSMIELITRFEKDHMNEIAALIGDDDINSFITEFLLVEPRLFIVYLGQCAAINWAFDIHYHRPSGKHQMGELLYSLLSRMSKGVYKIFTNALSHPKVYKKFWRSGVIEPIHGPSLDTQNLHVTVCDMIYGSYVTYLDLLLNDELDDYPYLLCESDEDVVTDRFDNIQAKHLCVLADVYCSSKRCPSIIGMSPIEKCTILTHYIKGESVQSPSGTSWNTDPLVVDHYSCSLTYLRCGSIKQIRLRVDPGFVFEALTDVDFKQPRKAKLDISVVGLTDFSPPCDNVGDFLGTINTLRHNLPVTGTGVSNYEVHAYRRIGLNSSACYKAVEISTLIRPSLEVGEHGLFLGEGSGSMLAAYKEVLKLANCYYNSGVTAEGRAGQREISPYPSEMSLVENQMGIERSVKVLFNGKPEVTWVGTTDCYKYIISNIQTSSLGFIHSDIETLPTKDAVEKLEEFASILSLSLILGKIGSITVVKVMPISGDFTQGFIAYAIQYFRESLLAYPRYSNFISTECYLIMIGLKANRLINPEAIKQSIIRAGVRTAPGLVSHILSGKQKGCIQSFLGDPYIQGDFNKHLKSLTPIEKILVNCGLSINGTKICRDLIHHDIASGPDGLMSSTIILYRELAHFKDNIRSQHGMFHPYPVLANSRQRELILRIAKKFWGYVLLYSDDPALIRQTIKNLKRNHLTFDLHSNPFIKGLSKAEKLLVRTSSLRREWLFTLDTKEVKEWFKLVGYSALIRG

MDSLSVNQVLYPEVHLDSPIVTNKLVAILEYSGIDHNYVLEDQTLVKNIRYRLGCGFSNQMIINNRGVGETVNSKLKSYPHNRHIIYPDCNKELFCIKDSCISKKLSELFKKGNSLYSKISHQVLDCLKRVNGKLGLGTDLTYGLKEGILDLGLHMHSSQWFETFLFWFTIKTEMRSMIKEQSHICHKRRYNPIFVSGDAFEVLVSRDLVVIIDKNTQYVFYLTFELVLMYCDVIEGRLMTETAMAIDQRYSELLSRVRYLWDLIDGFFPTLGNTTYQVVALLEPLSLAYLQLQDVTLELRGAFLDHCFKELYEILEHCGIDTEGTYNSITEGLDYVFITHDIHLTGEIFSFFRSFGHPRLEAVTAAENVRKHMNQPKVISYETMMKGHAVFCGIIINGFRDRHGGSWPPVALPEHASAAIRNAQASGEGLTHDLCIDNWKSFVGFKFGCFMPLSLDSDLTMYLKDKALAALKNEWDSVYPKEYLRYNPPRGTESRRLVEVFLNDSSFDPYNMIMYVVNGSYLKDPEFNLSYSLKEKEIKETGRLFAKMTYKMRACQVIAENLISNGVGKYFRDNGMAKDEHDLTKALHTLAVSGVPKNNKDNHRGGPPRRTTNREVRSSQDTKTQNRDKVQGGPVYNYLRCQPISPDQGESYETVSAFITADLKKYCLNWRYETISIFAQRLNEIYGLPSFFQWLHRILEKSVLYVSDPHCPPDLDNHIPLDSVPNAQIFIKYPMGGIEGYCQKLWTISTIPYLYLAAYESGVRIASLVQGDNQTIAVTKRVPSSWPYSLKKREASKAAQNYFVVLRQRLHDVGHHLKANETIVSSHFFVYSKGIYYDGLLVSQSLKSIARCVFWSETIVDETRAACSNIATTVAKSIERGYDRYLAYSLNILKIFQQILISLNFTINTTMTQDVVAPIIENGDLLIRMALLPAPIGGLNYLNMSRLFVRNIGDPVTSSIADLKRMIDAGLMPEETLHQVMTQTPGESSYLDWASDPYSANLPCVQSITRLLKNITARYILISSPNPMLKGLFHEGSRDEDEELASFLMDRHIIVPRAAHEILDHSITGAREAIAGMLDTTKGLIRTSMKRGGLTPRVLARLSNYDYEQFRSGITLLTKKGQCYLIDKDSCSVQLAIALRSHMWARLARGRPIYGLEVPDILESMNGYLIKRHESCAICETGSSHYGWFFVPAGCQLDDVSRETSALRVPYVGSTTEERTDMKLAFVRSPSRSLKSAVRIATVYSWAYGDDEKSWGEAWMLARQRANITLDELRMITPVSTSTNLAHRLRDRSTQVKYSGTSLVRVARYTTISNDNLSFVISEKKVDTNFIYQQGMLLGLGILENLFRLEATTGVSNTVLHLHVETECCVVPMVDHPRIPSLRNIKVTDELCTNPLIYDRSPIIEHDATRLYSQSHRRHLVEFVTWSTSQLYHILAKSTAMSMIELITRFEKDHMNEIAALIGDDDINSFITEFLLVEPRLFIVYLGQCAAINWAFDIHYHRPSGKHQMGELLYSLLSRMSKGVYKIFTNALSHPKVYKKFWRSGVIEPIHGPSLDTQNLHVTVCDMIYGSYVTYLDLLLNDELDDYPYLLCESDEDVVTDRFDNIQAKHLCVLADVYCSSKRCPSIIGMSPIEKCTILTHYIKGESVQSPSGTSWNTDPLVVDHYSCSLTYLRCGSIKQIRLRVDPGFVFEALTDVDFKQPRKAKLDISVVGLTDFSPPCDNVGDFLGTINTLRHNLPVTGTGVSNYEVHAYRRIGLNSSACYKAVEISTLIRPSLEVGEHGLFLGEGSGSMLAAYKEVLKLANCYYNSGVTAEGRAGQREISPYPSEMSLVENQMGIERSVKVLFNGKPEVTWVGTTDCYKYIISNIQTSSLGFIHSDIETLPTKDAVEKLEEFASILSLSLILGKIGSITVVKVMPISGDFTQGFIAYAIQYFRESLLAYPRYSNFISTECYLIMIGLKANRLINPEAIKQSIIRAGVRTAPGLVSHILSGKQKGCIQSFLGDPYIQGDFNKHLKSLTPIEKILVNCGLSINGTKICRDLIHHDIASGPDGLMSSTIILYRELAHFKDNIRSQHGMFHPYPVLANSRQRELILRIAKKFWGYVLLYSDDPALIRQTIKNLKRNHLTFDLHSNPFIKGLSKAEKLLVRTSSLRREWLFTLDTKEVKEWFKLVGYSALIRG
Protein #2 509 residues (31% resolved)

MAEEQAYHVNKGLECIKSLKASPPDLSTIRDTIESWREGLSPSGRATPNPDTSEGDHQSINQSCSPAIGPNKVYLSPGDNLGFREITGNDCEAGLGGVQGKRSNSQVQRYYVYSHGGEEIEGLEDADSLVVQADPPVANVFNGGEDGSDDSDVDSGPDDPSRDTLYDRGSVAGNDVARSTDVEKLEGADIQEVLNSQKGKGGRFQGGKTLRVPEIPDVKHSRPSAQSIKKGTDGNSVSSGTVTECLSISGATQAVPESRWESSEQNASVGSVLKSARSAETIQGLTQESGTIASLTQPKENDSEYEYEDDLFKEIQDIRASIAKIHDDNKTILSKLDSILLLKGEVDTIKKQISKQNISISTIEGHLSSIMIAIPGFGKDIKDPTSEVELNPDLRPIISRDSGRALAEVLKKPAVDRSQKIGTKANSSSKGQLLKDLQLKPVDKQASSAIGFVPSDHESSRNVIRSIIKSSKLNTDHKDYLLDLLNDVKGSKDLKEFHKMLTAILAKHP

MAEEQAYHVNKGLECIKSLKASPPDLSTIRDTIESWREGLSPSGRATPNPDTSEGDHQSINQSCSPAIGPNKVYLSPGDNLGFREITGNDCEAGLGGVQGKRSNSQVQRYYVYSHGGEEIEGLEDADSLVVQADPPVANVFNGGEDGSDDSDVDSGPDDPSRDTLYDRGSVAGNDVARSTDVEKLEGADIQEVLNSQKGKGGRFQGGKTLRVPEIPDVKHSRPSAQSIKKGTDGNSVSSGTVTECLSISGATQAVPESRWESSEQNASVGSVLKSARSAETIQGLTQESGTIASLTQPKENDSEYEYEDDLFKEIQDIRASIAKIHDDNKTILSKLDSILLLKGEVDTIKKQISKQNISISTIEGHLSSIMIAIPGFGKDIKDPTSEVELNPDLRPIISRDSGRALAEVLKKPAVDRSQKIGTKANSSSKGQLLKDLQLKPVDKQASSAIGFVPSDHESSRNVIRSIIKSSKLNTDHKDYLLDLLNDVKGSKDLKEFHKMLTAILAKHP
Non polymer #3 A1EF9

InChI=1S/C23H30F3N5O4S/c1-29-20(16-21(28-29)23(24,25)26)22(32)27-17-5-7-19(8-6-17)36(33,34)31-10-3-2-4-18(31)9-11-30-12-14-35-15-13-30/h5-8,16,18H,2-4,9-15H2,1H3,(H,27,32)/t18-/m0/s1

Cn1c(cc(n1)C(F)(F)F)C(=O)Nc2ccc(cc2)S(=O)(=O)N3CCCC[C@H]3CCN4CCOCC4
Non polymer #4 ZN

InChI=1S/Zn/q+2

[Zn+2]
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Reference