2026-04-25_00000007|ligand|11AD

Structural basis for high-affinity inhibitor binding to lipid kinases PIP4K2A and PIP4K2B; X-ray diffraction 2.79Å
Protein #1 377 residues (84% resolved)

GSHMASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEEEGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHIL

GSHMASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEEEGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHIL
Non polymer #2 A1C8V

InChI=1S/C24H24Cl2N6O2/c1-31-20-13-28-24(29-15-10-17(25)21(33)18(26)11-15)30-22(20)32(16-7-2-3-8-16)19(23(31)34)12-14-6-4-5-9-27-14/h4-6,9-11,13,16,19,33H,2-3,7-8,12H2,1H3,(H,28,29,30)/t19-/m1/s1

CN1c2cnc(nc2N([C@@H](C1=O)Cc3ccccn3)C4CCCC4)Nc5cc(c(c(c5)Cl)O)Cl
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Reference