2026-04-18_00000174
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ligand
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9Q8G
Crystal structure of the human METTL3-METTL14 in complex with small molecule inhibitor Compound 4 / EP102;
X-ray diffraction 1.75Å
Protein #1
213 residues (100% resolved)
Raw Sequence ...
ADRLFPPQWI(CSO)CDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQRYPDGIISKP
Canonical Sequence ...
ADRLFPPQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQRYPDGIISKP
Protein #2
279 residues (91% resolved)
Raw Sequence ...
NDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERL
Canonical Sequence ...
NDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERL
Non polymer #3
A1I4I
InChI=1S/C27H32N6OS/c1-2-22(29-11-18-3-4-18)15-33(9-1)23-7-8-24(30-14-23)27(16-34-17-27)26-32-31-25(35-26)21-10-20(12-28-13-21)19-5-6-19/h7-8,10,12-14,18-19,22,29H,1-6,9,11,15-17H2/t22-/m1/s1
InChI=1S/C27H32N6OS/c1-2-22(29-11-18-3-4-18)15-33(9-1)23-7-8-24(30-14-23)27(16-34-17-27)26-32-31-25(35-26)21-10-20(12-28-13-21)19-5-6-19/h7-8,10,12-14,18-19,22,29H,1-6,9,11,15-17H2/t22-/m1/s1
SMILES: c1cc(ncc1N2CCC[C@H](C2)NCC3CC3)C4(COC4)c5nnc(s5)c6cc(cnc6)C7CC7
c1cc(ncc1N2CCC[C@H](C2)NCC3CC3)C4(COC4)c5nnc(s5)c6cc(cnc6)C7CC7
Biounit #1
hetero-1-1-mer
Download coordinates
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Model
Reference
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