2026-04-18_00000023|hard|21BH

Cryo-EM structure of type VII CRISPR-Cas complex at the target engagement state; Electron microscopy 3.10Å
Protein #1 200 residues (100% resolved)

MAKTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATDRFLK

MAKTMKKIYVTMKTLSPLYTGEVRREDKEAAQKRVNFPVRKTATNKVLIPFKGALRSALEIMLKAKGENVCDTGESRARPCGRCVTCSLFGSMGRAGRASVDFLISNDTKEQIVRESTHLRIERQTKSASDTFKGEEVIEGATFTATITISNPQEKDLSLIQSALKFIEENGIGGWLNKGYGRVSFEVKSEDVATDRFLK
Protein #2 240 residues (100% resolved)

MKEIKGILESITGFSIPLDNGEYALYPAGRHLRGAIGYIAFNLDLPISSKFLDFDFDDIIFRDLLPISKCGKIFYPEKNSNSLKCPSCNEIYGSSVLRNIMARGLSYKEVIEGKKYRLSIIVKDEKYLNEMEAIIRYILSYGIYLGNKVSKGYGKFKIKEYSIVDILPVKDSEVLLLSDAIIDNGEKDIVFSKKEISSSKFEIIRKRGKAKGDIIRDNNHNGFYIGKYGGLGFGEIISLK

MKEIKGILESITGFSIPLDNGEYALYPAGRHLRGAIGYIAFNLDLPISSKFLDFDFDDIIFRDLLPISKCGKIFYPEKNSNSLKCPSCNEIYGSSVLRNIMARGLSYKEVIEGKKYRLSIIVKDEKYLNEMEAIIRYILSYGIYLGNKVSKGYGKFKIKEYSIVDILPVKDSEVLLLSDAIIDNGEKDIVFSKKEISSSKFEIIRKRGKAKGDIIRDNNHNGFYIGKYGGLGFGEIISLK
Protein #3 609 residues (95% resolved)

MIKFIGGASKVTGSAFLLETGNAKILIDCGIEQEKGIEKDNNEIIEKKINEIGKADICILTHAHLAASGLVPLLVKKRKVNKIISTPATKELCRLLFNDFQRIQEENNDIPLYSYDDIESSFEIWDEIDDRNTIELFDTKITFYNNSHIIGSVSVFIETHNGNYLFSGDIGSKLQQLMDYPPDMPDGNVDYLILESTYGNKSHDSSDRDRLLEIAKTTCENGGKVLIPSFAIGRLQEVLYTFSNYNFNFPVYIDSPMGSKVTNLIKEYNIYLKKKLRRLSITDDLFNNKYIAINTSNQSKELSNSKEPAVIISASGMLEGGRILNHLEQIKNDENSTLIFVGYQAQNTRGRKILDGEEKVRCRIEKLNSFSAHADQDELIDYIERLKYTPYKVFLVHGEKEQREILAKRIISKKIRVELPENYSQGKEILIEKKVVLNINTDNMCNFASYRLMPFSGFIVEKDDRIEINDKNWFDMIWNEEYNKMRSQIVAEDFSTDQNEDSMALPDMSHDKIIENIEYLFNIKILSKNRIKEFWEEFCKGQKAAIKYITQVHRKNPNTGRRNWNPPEGDFTDNEIEKLYETAYNTLLSLIKYDKNKVYNILINFNPKL

MIKFIGGASKVTGSAFLLETGNAKILIDCGIEQEKGIEKDNNEIIEKKINEIGKADICILTHAHLAASGLVPLLVKKRKVNKIISTPATKELCRLLFNDFQRIQEENNDIPLYSYDDIESSFEIWDEIDDRNTIELFDTKITFYNNSHIIGSVSVFIETHNGNYLFSGDIGSKLQQLMDYPPDMPDGNVDYLILESTYGNKSHDSSDRDRLLEIAKTTCENGGKVLIPSFAIGRLQEVLYTFSNYNFNFPVYIDSPMGSKVTNLIKEYNIYLKKKLRRLSITDDLFNNKYIAINTSNQSKELSNSKEPAVIISASGMLEGGRILNHLEQIKNDENSTLIFVGYQAQNTRGRKILDGEEKVRCRIEKLNSFSAHADQDELIDYIERLKYTPYKVFLVHGEKEQREILAKRIISKKIRVELPENYSQGKEILIEKKVVLNINTDNMCNFASYRLMPFSGFIVEKDDRIEINDKNWFDMIWNEEYNKMRSQIVAEDFSTDQNEDSMALPDMSHDKIIENIEYLFNIKILSKNRIKEFWEEFCKGQKAAIKYITQVHRKNPNTGRRNWNPPEGDFTDNEIEKLYETAYNTLLSLIKYDKNKVYNILINFNPKL
RNA #4 54 bases

GGUUAAAACUCUUCUCAUGCUGGAUUCGAAAUUAGUUUAAGUCCCAUAUGGUGG

GGUUAAAACUCUUCUCAUGCUGGAUUCGAAAUUAGUUUAAGUCCCAUAUGGUGG
RNA #5 60 bases

GAACAGAAGAACACCCAAUAGCGAAGCGCACCUAAUUUCGAAUCCAGCAUGAGAAGCUAA

GAACAGAAGAACACCCAAUAGCGAAGCGCACCUAAUUUCGAAUCCAGCAUGAGAAGCUAA
Non polymer #6 ZN

InChI=1S/Zn/q+2

[Zn+2]
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Reference