2026-04-11_00000030|ligand|29TQ

Three viral endonucleases bound to the same inhibitor (9-hydroxy-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione derivative). (3) Lassa virus L protein endonuclease with manganese ions.; X-ray diffraction 2.70Å
Protein #1 175 residues (100% resolved)

GMEEDIACVKDLVSKYLADNERLSRQKLAFLVQTEPRMLLMEGLKLLSLCIEIDSCNANGCEHNSEDKSVERILHDHGILTPSLCFVVPDGYKLTGNVLILLECFVRSSPANFEQKYIEDFKKLEQLKEDLKTVNISLIPLIDGRTSFYNEQIPDWVNDKLRDTLFSLLRYAQES

GMEEDIACVKDLVSKYLADNERLSRQKLAFLVQTEPRMLLMEGLKLLSLCIEIDSCNANGCEHNSEDKSVERILHDHGILTPSLCFVVPDGYKLTGNVLILLECFVRSSPANFEQKYIEDFKKLEQLKEDLKTVNISLIPLIDGRTSFYNEQIPDWVNDKLRDTLFSLLRYAQES
Non polymer #2 A1J4F

InChI=1S/C23H29N3O3/c1-16(2)25-13-14-26-18(24-21(28)20(27)19(26)22(25)29)15-23(11-7-4-8-12-23)17-9-5-3-6-10-17/h3,5-6,9-10,16,27H,4,7-8,11-15H2,1-2H3

CC(C)N1CCN2C(=NC(=O)C(=C2C1=O)O)CC3(CCCCC3)c4ccccc4
Non polymer #3 MN

InChI=1S/Mn/q+2

[Mn+2]
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Reference