2026-04-11_00000004
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ligand
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10OU
FGFR2 mutant D650V with compound 12;
X-ray diffraction 1.77Å
Protein #1
324 residues (95% resolved)
Raw Sequence ...
MGSSHHHHHHSQDPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARVINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE
Canonical Sequence ...
MGSSHHHHHHSQDPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARVINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE
Non polymer #2
A1C67
InChI=1S/C21H23N7O/c1-4-20(29)24-14-6-7-16-17(13-27(3)19(16)10-14)18-8-9-22-21(26-18)25-15-11-23-28(5-2)12-15/h6-13H,4-5H2,1-3H3,(H,24,29)(H,22,25,26)
InChI=1S/C21H23N7O/c1-4-20(29)24-14-6-7-16-17(13-27(3)19(16)10-14)18-8-9-22-21(26-18)25-15-11-23-28(5-2)12-15/h6-13H,4-5H2,1-3H3,(H,24,29)(H,22,25,26)
SMILES: CCC(=O)Nc1ccc2c(c1)n(cc2c3ccnc(n3)Nc4cnn(c4)CC)C
CCC(=O)Nc1ccc2c(c1)n(cc2c3ccnc(n3)Nc4cnn(c4)CC)C
Non polymer #3
EDO
InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
SMILES: C(CO)O
C(CO)O
Biounit #1
monomer
Download coordinates
Biounit #2
monomer
Download coordinates
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Model
Reference
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