2026-04-11_00000003|ligand|10OQ

FGFR2 mutant D650V with compound 6; X-ray diffraction 1.98Å
Protein #1 324 residues (94% resolved)

MGSSHHHHHHSQDPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARVINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE

MGSSHHHHHHSQDPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARVINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE
Non polymer #2 A1C66

InChI=1S/C26H27ClN6O2/c1-3-24(34)29-18-6-9-20-21(16-32(2)23(20)14-18)25-22(27)15-28-26(31-25)30-17-4-7-19(8-5-17)33-10-12-35-13-11-33/h4-9,14-16H,3,10-13H2,1-2H3,(H,29,34)(H,28,30,31)

CCC(=O)Nc1ccc2c(c1)n(cc2c3c(cnc(n3)Nc4ccc(cc4)N5CCOCC5)Cl)C
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Reference