2026-04-04_00000350|ligand|9Y8O

Crystal structure of the Kelch domain of human KLHL12 with compound 9c; X-ray diffraction 1.29Å
Protein #1 295 residues (97% resolved)

GSHMGSANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLRE

GSHMGSANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLRE
Non polymer #2 A1CTM

InChI=1S/C24H20Cl2N4O3/c1-14-6-5-9-19-22(14)29-24(27)30(19)12-21(32)28-23-17(25)10-15(11-18(23)26)20(31)13-33-16-7-3-2-4-8-16/h2-11H,12-13H2,1H3,(H2,27,29)(H,28,32)

Cc1cccc2c1nc(n2CC(=O)Nc3c(cc(cc3Cl)C(=O)COc4ccccc4)Cl)N
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Reference