2026-04-04_00000348|ligand|9Y8M

Crystal structure of the Kelch domain of human KLHL12 with compound 8i; X-ray diffraction 1.33Å
Protein #1 295 residues (97% resolved)

GSHMGSANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLRE

GSHMGSANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLRE
Non polymer #2 A1CTE

InChI=1S/C16H12Cl3FN4O/c1-7-11(20)2-3-12-14(7)23-16(21)24(12)6-13(25)22-15-9(18)4-8(17)5-10(15)19/h2-5H,6H2,1H3,(H2,21,23)(H,22,25)

Cc1c(ccc2c1nc(n2CC(=O)Nc3c(cc(cc3Cl)Cl)Cl)N)F
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