2026-04-04_00000347|ligand|9Y8L

Crystal structure of the Kelch domain of human KLHL12 with compound 8e; X-ray diffraction 1.27Å
Protein #1 295 residues (97% resolved)

GSHMGSANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLRE

GSHMGSANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLRE
Non polymer #2 A1CTQ

InChI=1S/C17H15Cl3N4O/c1-8-3-13-14(4-9(8)2)24(17(21)22-13)7-15(25)23-16-11(19)5-10(18)6-12(16)20/h3-6H,7H2,1-2H3,(H2,21,22)(H,23,25)

Cc1cc2c(cc1C)n(c(n2)N)CC(=O)Nc3c(cc(cc3Cl)Cl)Cl
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Reference