2026-03-21_00000034|ligand|24IC

Crystal structure of human RIPK1 kinase domain in complex with compound HR97; X-ray diffraction 2.70Å
Protein #1 294 residues (90% resolved)

MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE

MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE
Non polymer #2 A1E6R

InChI=1S/C25H26N6O4/c1-31-19-12-17(23(32)26-13-16-7-8-16)9-10-20(19)35-14-18(25(31)34)27-24(33)22-28-21(29-30-22)11-15-5-3-2-4-6-15/h2-6,9-10,12,16,18H,7-8,11,13-14H2,1H3,(H,26,32)(H,27,33)(H,28,29,30)/t18-/m0/s1

CN1c2cc(ccc2OC[C@@H](C1=O)NC(=O)c3[nH]c(nn3)Cc4ccccc4)C(=O)NCC5CC5
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Reference