2026-03-07_00000243|hard|9TOY

Investigating the binding mechanism of Interferon Regulatory Factor 4 to DNA in the context of Multiple Myeloma; X-ray diffraction 2.10Å

Protein #1 123 residues (93% resolved)

GPGGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQL

GPGGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQL

DNA #2 20 bases

(DT)(DC)(DA)(DA)(DC)(DT)(DG)(DA)(DA)(DA)(DC)(DT)(DG)(DA)(DG)(DA)(DA)(DA)(DG)(DC)

TCAACTGAAACTGAGAAAGC

DNA #3 20 bases

(DA)(DG)(DC)(DT)(DT)(DT)(DC)(DT)(DC)(DA)(DG)(DT)(DT)(DT)(DC)(DA)(DG)(DT)(DT)(DG)

AGCTTTCTCAGTTTCAGTTG

Non polymer #4 CA

[Ca+2]

Biounit #1 hetero-2-1-1-mer

Biounit #2 hetero-2-1-1-mer

Reference