2026-02-28_00000225
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ligand
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9P6F
Structure of the SARS-CoV-2 main protease in complex with inhibitor SR-B-78;
X-ray diffraction 1.80Å
Protein #1
306 residues (100% resolved)
Raw Sequence ...
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
Canonical Sequence ...
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
Non polymer #2
A1CG8
InChI=1S/C24H32F3N5O4/c1-22(2,3)18(31-21(35)24(25,26)27)20(34)32-11-14-16(23(14,4)5)17(32)19(33)30-15(8-28)12-7-13(36-6)10-29-9-12/h7-10,14-18,28H,11H2,1-6H3,(H,30,33)(H,31,35)/b28-8-/t14-,15+,16-,17-,18+/m0/s1
InChI=1S/C24H32F3N5O4/c1-22(2,3)18(31-21(35)24(25,26)27)20(34)32-11-14-16(23(14,4)5)17(32)19(33)30-15(8-28)12-7-13(36-6)10-29-9-12/h7-10,14-18,28H,11H2,1-6H3,(H,30,33)(H,31,35)/b28-8-/t14-,15+,16-,17-,18+/m0/s1
SMILES: [H]/N=C\[C@H](c1cc(cnc1)OC)NC(=O)[C@@H]2[C@@H]3[C@@H](C3(C)C)CN2C(=O)[C@H](C(C)(C)C)NC(=O)C(F)(F)F
[H]/N=C\[C@H](c1cc(cnc1)OC)NC(=O)[C@@H]2[C@@H]3[C@@H](C3(C)C)CN2C(=O)[C@H](C(C)(C)C)NC(=O)C(F)(F)F
Biounit #1
homo-dimer
Download coordinates
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Model
Reference
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