2026-02-28_00000130|ligand|9LZV

Crystal structure of human glutaminyl cyclase in complex with Inhibitor M-42; X-ray diffraction 2.33Å
Protein #1 329 residues (98% resolved)

ASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL

ASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
Non polymer #2 A1EMG

InChI=1S/C29H29N5O5/c1-37-26-8-3-18(13-27(26)38-2)14-28(35)33-11-9-20(10-12-33)39-21-5-7-23-25(16-21)34(29(36)32-23)19-4-6-22-24(15-19)31-17-30-22/h3-8,13,15-17,20H,9-12,14H2,1-2H3,(H,30,31)(H,32,36)

COc1ccc(cc1OC)CC(=O)N2CCC(CC2)Oc3ccc4c(c3)N(C(=O)N4)c5ccc6c(c5)nc[nH]6
Non polymer #3 ZN

InChI=1S/Zn/q+2

[Zn+2]
Download coordinates
Reference