2026-02-28_00000112|hard|9LLI

Cryo-EM structure of D1R in complex with de novo designed GEM targeting TM1/2/4 and GEM targeting TM3/4/5, and negative allosteric GEM targeting TM5/6/7; Electron microscopy 3.00Å
Protein #1 519 residues (66% resolved)

RTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSNHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRILKKELDALNDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRDAILKPFIEELKELKGKPFLIDAVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPTGGS

RTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSNHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRILKKELDALNDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRDAILKPFIEELKELKGKPFLIDAVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPTGGS
Protein #2 97 residues (70% resolved)

DYKDDDDKEFLEVLFQGPMLLIIGTIITLVSSIIFLISFFRFMRKWIRGLTRRDVRRFLVVLLVFFLLFLISLLLYVLFLVLYFLSLGKIDPKTGSA

DYKDDDDKEFLEVLFQGPMLLIIGTIITLVSSIIFLISFFRFMRKWIRGLTRRDVRRFLVVLLVFFLLFLISLLLYVLFLVLYFLSLGKIDPKTGSA
Protein #3 77 residues (86% resolved)

GPPLPLSKIVILLIILLILSIIFLLLLYLLIKYFKSFNEPIPPMLKVFLIYCVLSLIWVIIYTIIEVLELLLRPPPG

GPPLPLSKIVILLIILLILSIIFLLLLYLLIKYFKSFNEPIPPMLKVFLIYCVLSLIWVIIYTIIEVLELLLRPPPG
Protein #4 95 residues (69% resolved)

PSPVPPPPPPLPIWKILLIIGTILYIVVFLYISIFLYRLLKTFVPKEERKKWFKFLGILFLIFLILLIYFVVYVIRVLFPPPPPPSPGPPPPPPP

PSPVPPPPPPLPIWKILLIIGTILYIVVFLYISIFLYRLLKTFVPKEERKKWFKFLGILFLIFLILLIYFVVYVIRVLFPPPPPPSPGPPPPPPP
Non polymer #5 A1EKL

InChI=1S/C23H25F3N2OS/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29/h1-2,4-8,16,29H,3,9-15H2/b18-5-

c1ccc2c(c1)/C(=C/CCN3CCN(CC3)CCO)/c4cc(ccc4S2)C(F)(F)F
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Reference