2026-02-07_00000305|ligand|9Y0D

Crystal structure of human IgE Fab 2H22; X-ray diffraction 2.27Å
Protein #1 227 residues (98% resolved)

EVQLQESGPGLVKPSETLSLTCTVSGGSISTNGYYWGWIRQPPGKGLDWIGSISYSGNTYYNPSLQSRVSISVDTSKKQFSLKLSSVTASDTAVYYCARHGANWEGVVGWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC

EVQLQESGPGLVKPSETLSLTCTVSGGSISTNGYYWGWIRQPPGKGLDWIGSISYSGNTYYNPSLQSRVSISVDTSKKQFSLKLSSVTASDTAVYYCARHGANWEGVVGWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
Protein #2 216 residues (99% resolved)

QSVLPQPPSVSAAPGQNVTISCSGSISNIGNNYVSWYQRLPGTAPKLLIYGNNNRPSGIPDRFSGSKSATSATLGITGLQAGDEAVYYCGTWDSSLRAGVFGGGTQLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS

QSVLPQPPSVSAAPGQNVTISCSGSISNIGNNYVSWYQRLPGTAPKLLIYGNNNRPSGIPDRFSGSKSATSATLGITGLQAGDEAVYYCGTWDSSLRAGVFGGGTQLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
Non polymer #3 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
Non polymer #4 PEG

InChI=1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2

C(COCCO)O
Download coordinates
Reference